Current Intelligence Bulletin 11 – Dimethylcarbamoyl Chloride (DMCC) Revised

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Health hazards associated with dimethylcarbamoyl-chloride (79447) (DMCC) were discussed. The results of a bioassay showed that rats exposed by inhalation to 1 part per million DMCC developed squamous cell carcinomas of the nose within 200 days. These tumors were seen in 89 of 93 exposed rats. Earlier studies showed a high incidence of skin tumors and subcutaneous sarcomas along with some capillary tumors in the lung of ICR/Ha-Swiss-mice after subcutaneous and intraperitoneal injection of DMCC. Acute toxic effects of DMCC included irritation of the skin, eyes, and respiratory tract. In the United States (US), the only known uses of DMCC are as an intermediate in the synthesis of pharmaceuticals used in treating myasthenia gravis and as a reagent in the synthesis of carbamates. It was estimated that fewer than 200 persons in the US were potentially exposed to DMCC. Most of these would be intermittent exposures occurring in chemical laboratories. The author concludes that the very high incidence of nasal cancer and the short latency period seen in the most recent animal study suggest that a potentially serious hazard exists for workers exposed to DMCC. [Description provided by NIOSH]
• Subjects:
  Biological Assay Carcinogens Hazardous Substances Laboratories Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Bioassays Carcinogenesis Health-hazards In-vivo-studies Laboratory-animals NIOSH-Author NIOSH-Current-Intelligence-Bulletin-No-11 Occupational-exposure Organic-compounds Risk-analysis Risk-factors

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• Series:
  NIOSH Numbered Publications
• Subseries:
  Current Intelligence Bulletin
• DOI:
  https://doi.org/10.26616/NIOSHPUB7812711
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Handout/Flyer
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DCDSD - Division of Criteria Documents and Standards Development
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-2
• NIOSHTIC Number:
  nn:00170792
• NTIS Accession Number:
  PB83-105080
• Citation:
  Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-127, (CIB 11), 1976 Jul; :1-2
• CAS Registry Number:
  Dimethylcarbamoyl chloride (CAS RN 79-44-7)
• Federal Fiscal Year:
  1976
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e6286c3754f7cb82436f3731524c3d5223512196702629c39b483f035ad6ab488ca02d41a3e242d83db9e6a9dde999d0679c337228237cd6ebdb5b93acfb6804
• Download URL:
  https://stacks.cdc.gov/view/cdc/209486/cdc_209486_DS1.pdf
• File Type:
  [PDF - 398.20 KB ]