Health Hazard Alert: Benzidine-, O-Tolidine, and O-Dianisidine- Based Dyes

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Studies on the carcinogenicity and metabolism of benzidine (92875), o-tolidine (119937), and o-dianisidine (119904) based dyes are reviewed. Results of animal and human experiments are summarized. The authors conclude that exposure of workers to benzidine based dyes should be discontinued or reduced to the lowest possible concentrations. Exposure to o-tolidine and o-dianisidine based dyes should be limited. Recommendations to reduce worker exposure to these dyes include substituting less toxic dyes, establishing engineering controls for these chemicals, ensuring good housekeeping procedures and industrial hygiene practices, establishing restricted areas, informing employees of the adverse health effects of working with these dyes, placing employees with occupational exposure to these dyes under a medical monitoring program, providing facilities to remove residual chemicals, and monitoring employee exposures. [Description provided by NIOSH]
• Subjects:
  Animals Coloring Agents Occupational Health Polycyclic Aromatic Hydrocarbons Safety
• Keywords:
  Animal-studies Aromatic-hydrocarbons Dyes Humans Medical-research NIOSH-Author Safety-engineering Worker-health
• Series:
  NIOSH Numbered Publications
• DOI:
  https://doi.org/10.26616/NIOSHPUB81106
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DCDSD - Division of Criteria Documents and Standards Development
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-36
• NIOSHTIC Number:
  nn:00118761
• NTIS Accession Number:
  PB87-148219
• Citation:
  Rockville, MD: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 81-106, 1980 Dec; :1-36
• CAS Registry Number:
  4,4'-Diaminodiphenyl (CAS RN 92-87-5) ; Dianisidine (CAS RN 119-90-4) ; o-Tolidine (CAS RN 119-93-7)
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:64bb1545d5f71deed4485197dd64765cba3d835e857263d9922d79f70428e8f4272b81388db0298b24e496c5ec48bbd323f84471fbb0ff88065c3ce2cecc5315
• Download URL:
  https://stacks.cdc.gov/view/cdc/209425/cdc_209425_DS1.pdf
• File Type:
  [PDF - 1.33 MB ]