Development and Validation of Methods for Sampling and Analysis of Workplace Toxic Substances

Details

• Personal Author:
  Anderson CC ; Gunderson EC
• Description:
  Methods for sampling and analyzing 130 toxic workplace substances were evaluated. Analytical methods were developed and tested for the toxic substance. The sensitivity and specificity of the method were evaluated and the response to known interferences was determined. An appropriate sample collection medium was chosen and spiked with known amounts of the test substance. An efficient recovery procedure was developed. The analytic recovery of the substance from the sampling medium was then determined and the precision was evaluated. The efficiency of the sampling procedure with known air concentrations of the toxic substance was tested. Based on the results of the validation tests, an evaluation was made of the precision and accuracy of the analytical method alone and of the sampling and analytical method as a whole. Of the 130 substances studied on this program, methods were developed and validated for 92 substances. The authors conclude that these methods will provide a means by which worker exposures to specific toxic substances can be determined. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution, Indoor Chemistry Environmental Monitoring Occupational Health Safety
• Keywords:
  Air-contamination Air-sampling Chemical-analysis Contract-210-76-0123 Control-methods NIOSH-Contract Sample-preparation Sampling-methods Standards
• Series:
  NIOSH Numbered Publications
• DOI:
  https://doi.org/10.26616/NIOSHPUB80133
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DPSE - Division of Physical Sciences and Engineering
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-45
• NIOSHTIC Number:
  nn:00102922
• NTIS Accession Number:
  PB89-182042
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 80-133, 1980 Sep; :1-45
• Federal Fiscal Year:
  1980
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b4c357d0962ae0c47b5c3d80b7a50265ce788e6d1e8929b4b92cf2fbc9d598bbbcd99c6035aa62fc7e4114f1c34dad110291533de9a0dc0d49868a116eb0160f
• Download URL:
  https://stacks.cdc.gov/view/cdc/209393/cdc_209393_DS1.pdf
• File Type:
  [PDF - 4.31 MB ]