Special Occupational Hazard Review for Benzidine-Based Dyes

Details

• Personal Author:
  Bamel IP ; Gregory, Arthur R. ; Mackison, Frank W.
• Description:
  Information concerning the carcinogenicity and metabolism of benzidine (92875) based dyes is reviewed. Research has indicated that some of the dyes have induced tumors in animals; occupational exposure to benzidine based dye is related to an increased incidence of bladder cancer in workers; the dyes are metabolized in animals to the carcinogen benzidine; and the enzyme azoreductase, which breaks down these dyes to benzidine, is present in animals and humans. The carcinogenic impurities of 4-aminobiphenyl (92671) and 2,4- diaminoazobenzene (495545) were found in one benzidine based dye and may contribute to the dye's carcinogenic potential. The authors conclude that all benzidine based dyes should be recognized as potential human carcinogens. NIOSH recommends that the production, use, storage, packaging, and distribution of all benzidine based dyes be discontinued in light of present evidence of potential carcinogenic risks. [Description provided by NIOSH]
• Subjects:
  Carcinogens Coloring Agents Energy Metabolism Enzymes Manufacturing And Industrial Facilities Occupational Health Polycyclic Aromatic Hydrocarbons Risk Assessment Risk Factors Safety
• Keywords:
  Aromatic-hydrocarbons Dyestuffs Enzymatic-activity Materials-handling Metabolic-effects NIOSH-Author NIOSH-Criteria-Document Risk-factors Tumorigens
• Series:
  NIOSH Numbered Publications
• DOI:
  https://doi.org/10.26616/NIOSHPUB80109
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Standards
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DCDSD - Division of Criteria Documents and Standards Development
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-66
• NIOSHTIC Number:
  nn:00094105
• NTIS Accession Number:
  PB81-225633
• Citation:
  Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 80-109, 1980 Jan; :1-66
• CAS Registry Number:
  2,4-Diaminoazobenzene (CAS RN 495-54-5) ; 4,4'-Diaminodiphenyl (CAS RN 92-87-5) ; 4-Aminobiphenyl (CAS RN 92-67-1)
• Federal Fiscal Year:
  1980
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:edcaf68b4c1e6d875c4cd68767f14f12f3d31ca10d8bffc982ad911e950a40452b88b4448dcc8bec475d4f91b74ee5a8f42b62a31e22886f2686f2b608406808
• Download URL:
  https://stacks.cdc.gov/view/cdc/209371/cdc_209371_DS1.pdf
• File Type:
  [PDF - 2.87 MB ]