Estimates of Pulmonary and Gastrointestinal Deposition for Occupational Fiber Exposures

Details

• Personal Author:
  Dement, John M. ; Harris RL Jr.
• Description:
  The fraction of seven types of airborne fibers in 19 industrial settings predicted to be deposited in the deep pulmonary spaces and that fraction that might be ingested were estimated. Deposition estimates also were generated for fibers considered significant for tumor production. An unvalidated mathematical model for predicting the deposition of uniform straight rods of high aspect ratio was used. The pulmonary deposited fraction was considered to be those fibers deposited beyond the ciliated portion of the respiratory system. The ingested or gastrointestinal fraction was assumed to be those fibers cleared by the nasopharynx and tracheobronchial clearance processes and swallowed and was approximated based on the clearance to the gastrointestinal tract of all fibers deposited in the tracheobronchial compartment and 75 percent of those deposited in the nasopharynx beyond the nasal hairs. Partially quantitative results show that the numerical fractions estimated to be deposited in the pulmonary spaces ranged from approximately 3 to 16 percent, while the gastrointestinal fractions ranged from 11 to 59 percent. Large differences in deposition patterns for fibers in the size range considered most important for tumor production in laboratory animals by Stanton et al (1977) also were noted. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Asbestos Digestive System Digestive System Diseases Dust Glass Occupational Health Particulate Matter Safety
• Keywords:
  Aerosol-particles Airborne-particles Asbestos-dust Carcinogenic Contract-78-2438 Gastrointestinal-system-disorders Glass-fibers Industrial-health Lung-congestion NIOSH-Contract Pulmonary-fibrosis

  More +
• Series:
  NIOSH Numbered Publications
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-81
• NIOSHTIC Number:
  nn:00091510
• NTIS Accession Number:
  PB80-149644
• Citation:
  Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 79-135, 1979 Apr; :1-81
• Federal Fiscal Year:
  1979
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5d7b08df8272bfa2d6591abcff8533e6d025c7c9aac1cc4f93c4bedda8612a4d1bd1ba99103b2ea28d7c1b147c90f1ca5304c63e2a92ddbe27c25e1cc0aa1a4f
• Download URL:
  https://stacks.cdc.gov/view/cdc/209349/cdc_209349_DS1.pdf
• File Type:
  [PDF - 2.52 MB ]