Decrements in Lung Function and Respiratory Abnormalities Associated with Exposure to Diacetyl and 2,3-Pentanedione in Coffee Production Workers

Details

• Personal Author:
  Apostoaei I ; Bertke S ; Boice JD Jr. ; Cohen SS ; Dauer LT ; Deffner V ; Demers PA ; Do M ; Eckerman KF ; Ellis ED ; Fenske N ; Golden A ; Hoffman FO ; Howard SC ; Kelly-Reif K ; Kreuzer M ; Laurier D ; Leggett RW ; Mumma MT ; Pasqual E ; Pawel DJ ; Rage E ; Richardson DB ; Samet J ; Schubauer-Berigan, Mary K. ; Simon SL ; Smith B ; Thomas BA ; Tomasek L ; Wiggins C ; Zablotska LB
• Description:
  Epidemiological studies of occupational, medical, and environmental exposures have provided important information on lung cancer risk and how those risks might depend on the type of exposure, dose rate, and other potential modifying factors such as sex and age of the exposed. Analyses of data from underground miner cohorts and residential case-control studies provide convincing evidence that radon is a leading cause of lung cancer. For low-LET radiation, risk models derived from results from the Lifespan Study of Japanese atomic bomb survivors suggest that for acute exposures, lifetime attributable risks for lung cancer are greater than for other specific cancer sites and are substantially larger for females than males. However, for protracted and fractionated exposures other than from radon, results from epidemiological studies are seemingly often contradictory. This report includes summaries of oral presentations during a symposium on radiogenic lung cancer risk given by a panel of experts on October 5 during the Radiation Research Society's 67th annual meeting. This session included presentations on: 1) the largest pooled study of male uranium miners (PUMA) exposed to radon; 2) the most recent analysis of the Canadian Fluoroscopy cohort featuring state-of-the-art dosimetry for radiation exposures associated with frequent medical diagnostic procedures; 3) an update from the Million Person Study on risks from fractionated occupational exposures, and 4) studies of second primary malignancies - including lung cancer - in patients who had been treated for thyroid cancer. [Description provided by NIOSH]
• Subjects:
  Aging Coal Coal Mining Diagnosis Epidemiology Lung Lung Diseases Mining Neoplasms Occupational Health Radiation Radiation Dosimeters Respiratory System Respiratory Tract Diseases Safety Uranium

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• Keywords:
  Age Groups Author Keywords: Ionizing Radiation Coal Mining Diagnostic Tests Dose Response Dosimetry Lung Cancer Medical Radon Risk Thyroid Gland Disorders Underground Mining Uranium Miners

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• ISSN:
  0955-3002
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; District of Columbia ; Iowa ; Maryland ; New Mexico ; New York ; North Carolina ; Ohio ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 7 ; OSHA Region 8 ; OSHA Region 9 ; Tennessee
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DFSE - Division of Field Studies and Engineering
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  99
• Issue:
  3
• NIOSHTIC Number:
  nn:20066001
• Citation:
  Int J Radiat Biol 2023 Mar; 99(3):569-580
• Contact Point Address:
  David J. Pawel, 7045 Alicent Place, McLean, VA 22101, USA
• Email:
  Paweld1511@protonmail.com
• CAS Registry Number:
  Radon (CAS RN 10043-92-2) ; Uranium (CAS RN 7440-61-1)
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of California, San Francisco
• Peer Reviewed:
  True
• Start Date:
  20180901
• Source Full Name:
  International Journal of Radiation Biology
• End Date:
  20200831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c2d19113fe026727ba8f23b91cf0cc8acb03360cd2fea568c283757b4670fa3d9369ece897f02e4c6e655492b7552986238ffc20fc511030aee995479f792d2e
• Download URL:
  https://stacks.cdc.gov/view/cdc/209091/cdc_209091_DS1.pdf
• File Type:
  [PDF - 1.84 MB ]