Temporary and Permanent Auditory Effects Associated with Occupational Coexposure to Low Levels of Noise and Solvents

Details

• Personal Author:
  Bailey, Rachel L. ; Blackley, Brie H. ; Cox-Ganser, Jean M. ; Cummings, Kristin J. ; Fechter-Leggett, Ethan D. ; Groth CP ; Harvey, R. Reid ; LeBouf, Ryan F. ; Liang X ; Stanton, Marcia L. ; Virji, M. Abbas
• Description:
  Coffee production workers are exposed to complex mixtures of gases, dust, and vapors, including the known respiratory toxins, diacetyl, and 2,3-pentanedione, which occur naturally during coffee roasting and are also present in flavorings used to flavor coffee. This study evaluated the associations of these two a-diketones with lung function measures in coffee production workers. Workers completed questionnaires, and their lung function was assessed by spirometry and impulse oscillometry (IOS). Personal exposures to diacetyl, 2,3-pentanedione, and their sum (SumDA+PD) were assigned to participants, and metrics of the highest 95th percentile (P95), cumulative, and average exposure were calculated. Linear and logistic regression models for continuous and binary/polytomous outcomes, respectively, were used to explore exposure-response relationships adjusting for age, body mass index, tenure, height, sex, smoking status, race, or allergic status. Decrements in percent predicted forced expiratory volume in 1 second (ppFEV1) and forced vital capacity (ppFVC) were associated with the highest-P95 exposures to 2,3-pentanedione and SumDA+PD. Among flavoring workers, larger decrements in ppFEV1 and ppFVC were associated with highest-P95 exposures to diacetyl, 2,3-pentanedione, and SumDA+PD. Abnormal FEV1, FVC, and restrictive spirometric patterns were associated with the highest-P95, cumulative, and average exposures for all a-diketone metrics; some of these associations were also present among flavoring and non-flavoring workers. The combined category of small and peripheral airways plus small and large airways abnormalities on IOS had elevated odds for highest-P95 exposure to a-diketones. These results may be affected by the small sample size, few cases of abnormal spirometry, and the healthy worker effect. Associations between lung function abnormalities and exposure to a-diketones suggest it may be prudent to consider exposure controls in both flavoring and non-flavoring settings. [Description provided by NIOSH]
• Subjects:
  Coffee Diacetyl Dust Hazardous Substances Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety Solvents
• Keywords:
  2,3-pentanedione Author Keywords: Coffee Production Coffee Workers Dusts Gases Impulse Oscillometry Lung Function Peak Exposures Respiratory Irritants Respiratory System Disorders Restrictive Pattern Small Airways Spirometry Toxins Vapors

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• ISSN:
  2296-2565
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  10
• NIOSHTIC Number:
  nn:20066000
• Citation:
  Front Public Health 2022 Aug; 10:966374
• Contact Point Address:
  Mohammed Abbas Virji, Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV
• Email:
  MVirji@cdc.gov
• CAS Registry Number:
  Acetylacetone (CAS RN 123-54-6) ; Butanedione (CAS RN 431-03-8)
• Federal Fiscal Year:
  2022
• Peer Reviewed:
  True
• Source Full Name:
  Frontiers in Public Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2ed389966ac193a9ee585b0c6563d55386d67d5b143f0e137547b4eada731fabef4621c28ae5505f5dc04659e42dc8d141b1b9d82a151fdf38bedab9789f2c01
• Download URL:
  https://stacks.cdc.gov/view/cdc/209090/cdc_209090_DS1.pdf
• File Type:
  [PDF - 1.17 MB ]