The Association Between Oil Spill Cleanup-Related Total Hydrocarbon Exposure and Diabetes

Details

• Personal Author:
  Curry MD ; Engel LS ; Jardel HV ; Kwok RK ; Lawrence KG ; Sandler DP ; Stenzel MR ; Stewart PA
• Description:
  Background: Although evidence suggests relationships between some crude oil components and glycemic dysregulation, no studies have examined oil spill-related chemical exposures in relation to type 2 diabetes mellitus (DM) risk. This study examined the relationship between total hydrocarbon (THC) exposure among workers involved in the 2010 Deepwater Horizon (DWH) oil spill and risk of DM up to 6 years afterward. Methods: Participants comprised 2660 oil-spill cleanup or response workers in the prospective GuLF Study who completed a clinical exam and had no self-reported DM diagnosis prior to the spill. Maximum THC exposure was estimated with a job-exposure matrix based on interview data and personal measurements taken during cleanup operations. We defined incident DM by self-reported physician diagnosis of DM, antidiabetic medication use, or a measured hemoglobin A1c value ≥ 6.5%. We used log binomial regression to estimate risk ratios (RRs) for DM across ordinal categories of THC exposure. The fully adjusted model controlled for age, sex, race/ethnicity, education, employment status, and health insurance status. We also stratified on clinical body mass index categories. Results: We observed an exposure-response relationship between maximum daily ordinal THC exposure level and incident DM, especially among overweight participants. RRs among overweight participants were 0.99 (95% CI: 0.37, 2.69), 1.46 (95% CI: 0.54, 3.92), and 2.11 (95% CI: 0.78, 5.74) for exposure categories 0.30-0.99 ppm, 1.00-2.99 ppm, and ≥3.00 ppm, respectively (ptrend = 0.03). Conclusion: We observed suggestively increasing DM risk with increasing THC exposure level among overweight participants, but not among normal weight or obese participants. [Description provided by NIOSH]
• Subjects:
  Blood Body Weight Cohort Studies Hematologic Diseases Hydrocarbons Occupational Health Safety
• Keywords:
  Author Keywords: Diabetes Blood Sugar Disorders Body Weight Cohort Studies Deepwater Horizon Disaster Clean-up GuLF Study Oil Spills Petroleum Hydrocarbons
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; North Carolina ; OSHA Region 3 ; OSHA Region 4 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  212
• NIOSHTIC Number:
  nn:20065973
• Citation:
  Environ Res 2022 Sep; 212(Pt E):113591
• Contact Point Address:
  H.V. Jardel, Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
• Email:
  jahan1@ad.unc.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of North Carolina, Chapel Hill
• Peer Reviewed:
  True
• Part Number:
  E
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:47367b8d22bfeae5ff4314f11d6c7cd444bc0b177984d01147d6827a96abfc2979dc1653f792d6a9bda6d7f16729c0aaec716602479a70fc5440821abc119bea
• Download URL:
  https://stacks.cdc.gov/view/cdc/209066/cdc_209066_DS1.pdf
• File Type:
  [PDF - 470.52 KB ]