A Comprehensive Summary of Disease Variants Implicated in Metal Allergy

Details

• Personal Author:
  Roach K ; Roberts J
• Description:
  Allergic disease represents one of the most prominent global public health crises of the 21st century. Although many different substances are known to produce hypersensitivity responses, metals constitute one of the major classes of allergens responsible for a disproportionately large segment of the total burden of disease associated with allergy. Some of the most prevalent forms of metal allergy - including allergic contact dermatitis - are well-recognized; however, to our knowledge, a comprehensive review of the many unique disease variants implicated in human cases of metal allergy is not available within the current scientific literature. Consequently, the main goal in composing this review was to (1) generate an up-to-date reference document containing this information to assist in the efforts of lab researchers, clinicians, regulatory toxicologists, industrial hygienists, and other scientists concerned with metal allergy and (2) identify knowledge gaps related to disease. Accordingly, an extensive review of the scientific literature was performed - from which, hundreds of publications describing cases of metal-specific allergic responses in human patients were identified, collected, and analyzed. The information obtained from these articles was then used to compile an exhaustive list of distinctive dermal/ocular, respiratory, gastrointestinal, and systemic hypersensitivity responses associated with metal allergy. Each of these disease variants is discussed briefly within this review, wherein specific metals implicated in each response type are identified, underlying immunological mechanisms are summarized, and major clinical presentations of each reaction are described. [Description provided by NIOSH]
• Subjects:
  Digestive System Digestive System Diseases Hypersensitivity Lung Diseases Metals Occupational Health Public Health Respiratory Tract Diseases Safety Skin
• Keywords:
  Allergic Reactions Author Keywords: Metal Allergy Contact Dermatitis Dermal Exposures Dermatitis Gastrointestinal System Disorders Immunotoxicity Occupational Health Public Health Pulmonary System Disorders Respiratory Hypersensitivity Respiratory System Disorders

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• ISSN:
  1093-7404
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  279-341
• Volume:
  25
• Issue:
  6
• NIOSHTIC Number:
  nn:20065951
• Citation:
  J Toxicol Environ Health B 2022 Aug; 25(6):279-341
• Contact Point Address:
  Ka Roach, 1000 Frederick Lane, Morgantown, WV 26508
• Email:
  WVQ1@cdc.gov
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part B: Critical Reviews
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7307375f0039cd7eab7635d0041df3f1df259cb9e9a5ea38a0252efc725120b501f92a63597e0dcae17f7f7ce35e55cb31345bdd7714e491a85976bb296f2b95
• Download URL:
  https://stacks.cdc.gov/view/cdc/209046/cdc_209046_DS1.pdf
• File Type:
  [PDF - 3.27 MB ]