Characterization of Change in Cognition Before and After COVID-19 Infection in Essential Workers at Midlife

Details

• Personal Author:
  Ali A ; Babalola T ; Carr MA ; Clouston SAP ; Fontana A ; Jiang E ; Luft BJ ; Mehta N ; Morozova O ; Sekendiz Z
• Description:
  Background: Research into COVID-19-related cognitive decline has focused on individuals who are cognitively impaired following hospitalization for COVID-19. Our objective was to determine whether cognitive decline emerged after the onset of COVID-19 and was more pronounced in patients with postacute sequelae of SARS-CoV-2 infection (PASC). Methods: We analyzed longitudinal cognitive data collected during a cohort study of essential workers at midlife that continued through the COVID-19 pandemic. We used longitudinal discontinuity models, a form of causal modeling, to examine the change in cognitive performance among 276 participants with COVID-19 in comparison to contemporaneously-collected information from 217 participants who did not have COVID-19. Cognitive performance across four domains was measured before and after the pandemic. Eligible study participants were those with validated COVID-19 diagnoses who were observed before having a verified COVID-19 infection who survived their initial infection, and for whom post-COVID-19 information was also available. Results: The mean age of the COVID-19 group was 56.0 +/- 6.6 years old, while the control group was 58.1 +/- 7.3 years old. Longitudinal models indicated a significant decline in cognitive throughput (β = -0.168, P = .001) following COVID-19, after adjustment for pre-COVID-19 functioning, demographics, and medical factors. Associations were larger in those with more severe COVID-19 and those who reported PASC. Observed changes in throughput were equivalent to 10.6 years of normal aging. Conclusion: Findings from this longitudinal causal modeling study revealed that COVID-19 and PASC appeared to cause clinically relevant cognitive deterioration. [Description provided by NIOSH]
• Subjects:
  Aging Communicable Diseases Nervous System Occupational Health Safety
• Keywords:
  Author Keywords: Coronavirus Disease 2019 Cognitive Function COVID-19 Covid-19 Related Cognitive Decline CRCD Executive Dysfunction Longitudinal Study PASC Postacute Sequelae Of SARS-CoV-2 SARS-CoV-2 Severe Acute Respiratory Syndrome Coronavirus 2

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• ISSN:
  2667-0364
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Chicago Region [OSHA] ; Illinois ; New York ; New York City Region [OSHA]
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  12
• NIOSHTIC Number:
  nn:20070636
• Citation:
  Am J Med Open 2024 Dec; 12:100076
• Contact Point Address:
  Sean Clouston, PhD, Program in Public Health, Stony Brook University, 101 Nichols rd., Stony Brook, NY, 11794, USA
• Email:
  sean.clouston@stonybrookmedicine.edu
• Federal Fiscal Year:
  2025
• Performing Organization:
  State University of New York at Stony Brook
• Peer Reviewed:
  True
• Start Date:
  20210701
• Source Full Name:
  American Journal of Medicine Open
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:dd7a3e9aee30327bb7d13b9baa4ae56fd57e87094c0491247a5d9ad9485bc660dac58a5a6718030fa9a392477d0a9a4e97485b4f2c76eac96e873eb3cb14e585
• Download URL:
  https://stacks.cdc.gov/view/cdc/208815/cdc_208815_DS1.pdf
• File Type:
  [PDF - 977.43 KB ]