Prenatal Exposure to Metals and Autism Spectrum Disorder: Current Status and Future Directions

Details

• Personal Author:
  Bakulski KM ; Campbell KA ; Fallin MD ; Hickman R
• Description:
  Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with genetic and environmental contributors to etiology. Many metals have the potential to be neurotoxic, and their exposures are widespread. The field of metals exposure and ASD research is emerging, and in this review article, we assess the current state of the literature, with emphasis on the previous 2 years. Epidemiology studies are discussed with respect to exposure timing, exposure matrix, and outcome assessment. Toxicology studies are described for exposure dosing and timing, as well as behavioral and molecular outcomes. Further epidemiological and toxicological investigations can identify the timing and importance of metals as ASD risk factors and uncover biological mechanisms for risk mitigation and therapeutic strategies. [Description provided by NIOSH]
• Subjects:
  Epidemiology Metals Nervous System Occupational Health Pregnancy Safety
• Keywords:
  ASDs Author Keywords: Metals Autism Spectrum Disorder Autism Spectrum Disorders Chemical Exposure Neurodevelopment Neurotoxic Effects Neurotoxicology Prenatal Exposure
• ISSN:
  2468-2020
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Michigan ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  39-48
• Volume:
  26
• NIOSHTIC Number:
  nn:20070612
• Citation:
  Curr Opin Toxicol 2021 Jun; 26:39-48
• Contact Point Address:
  Margaret Daniele Fallin, Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
• Email:
  dfallin@jhu.edu
• CAS Registry Number:
  N-Acetyl-L-cysteine (CAS RN 616-91-1) ; Trichloroethylene (CAS RN 79-01-6)
• Federal Fiscal Year:
  2021
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Current Opinion in Toxicology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c176a8475faf4172be917154f49ef9788a6809392caa1fa218d0ad10ae2a7a67747df9ca3fed04c1fcd6c4f91718bd1cf9c4ce6d4336172b88b35ac8fc29d4ae
• Download URL:
  https://stacks.cdc.gov/view/cdc/208791/cdc_208791_DS1.pdf
• File Type:
  [PDF - 681.13 KB ]