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Influence of Work Intensity on Acute Kidney Injury Risk During Simulated Occupational Heat Stress



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  • Personal Author:
  • Description:
    Violation of the National Institute of Occupational Safety and Health (NIOSH) heat stress recommendations by exceeding the allowable wet bulb globe temperature (WBGT) for a given work intensity and work-rest ratio augments acute kidney injury (AKI) risk. Here we tested the hypothesis that exceeding the allowable work intensity at a given WBGT and work-rest ratio would also worsen AKI risk. Twelve healthy adults completed two NIOSH recommendation compliant trials and one noncompliant trial consisting of a 4 h (half workday) exposure. Work-rest ratio was fixed at 30 min of walking and 30 min of rest each hour. Work intensity (metabolic heat production) was prescribed as a function of WBGT- 412 +/- 51 W (27.3 +/- 0.3 degrees C; high intensity compliant [Chigh]), 290 +/- 75 W (31.6 +/- 0.2 degrees C; low intensity compliant [Clow]), and 410 +/- 61 W (31.7 +/- 0.2 degrees C; high intensity noncompliant [NChigh]). AKI risk was quantified by the product of urinary insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 normalized to urine specific gravity ([IGFBP7oTIMP-2]USG). Peak core temperature was higher in NChigh trial (38.3 +/- 0.4 degrees C) compared to the compliant trials (Chigh: 38.0 +/- 0.3 degrees C; Clow: 37.8 +/- 0.4 degrees C; p=0.0095). [IGFBP7oTIMP-2]USG increased from pre- to immediately postexposure in all trials (time effect: p=0.0454) but the peak increase was not different between trials (Chigh: 0.89 +/- 1.7 [ng/mL]2/1000; Clow: 0.78 +/- 1.7 [ng/mL]2/1000; NChigh: 1.0 +/- 1.4 [ng/mL]2/1000; p=0.7811). Violating the NIOSH recommendations by exceeding either the allowable work intensity (i.e., NChigh versus Clow) or WBGT (i.e., NChigh versus Chigh) resulted in a modest elevation in peak core temperature but did not modify AKI risk. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    8750-7587
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    138
  • Issue:
    3
  • NIOSHTIC Number:
    nn:20070476
  • Citation:
    J Appl Physiol 2025 Mar; 138(3):706-717
  • Contact Point Address:
    Zachary J. Schlader, Department of Kinesiology, Indiana University School of Public Health-Bloomington, Bloomington, Indiana, United States
  • Email:
    zschlade@iu.edu
  • Federal Fiscal Year:
    2025
  • Performing Organization:
    Indiana University, Bloomington
  • Peer Reviewed:
    True
  • Start Date:
    20190901
  • Source Full Name:
    Journal of Applied Physiology
  • End Date:
    20240831
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:3954875820bc4f8acc84276965d268dab4b12f5067acdbb34992b841e7a9b8054287e51c7d3ea15d94160013dd2ed0d710465a62d687f4ae6aaa749b39f1663e
  • Download URL:
  • File Type:
    Filetype[PDF - 949.17 KB ]
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