The Effect of Consuming a Sucrose-Containing Sports Drink on Acute Kidney Injury Risk During a 4 H Simulated Occupational Heat Stress

Details

• Personal Author:
  Freemas JA ; Hess HW ; Hostler D ; Johnson BD ; Lignier MJ ; Schlader ZJ
• Description:
  Occupational heat stress increases acute kidney injury risk. Drinking a soft drink sweetened with high fructose corn syrup further elevates this acute kidney injury risk. However, the impact of sucrose, another fructose-containing sweetener, on acute kidney injury risk remains unexplored. We tested the hypothesis that drinking a sucrose-containing sports drink increases acute kidney injury risk when compared to drinking a sugar-free sports drink during 4 h of simulated occupational heat stress. Ten healthy adults consumed a sucrose-containing or sugar-free sport drink ad libitum during 4 h exposures to wet bulb globe temperatures of approximately 28 degrees C. Thirty min of work and 30 min of rest were completed each hour. Work involved treadmill walking at a fixed rate of metabolic heat production (sucrose-containing: 6.0 +/- 1.2 W/kg, sugar-free: 5.5 +/- 0.9 W/kg, p = 0.267). The product of urinary insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase-2, normalized to urine specific gravity ([IGFBP7·TIMP-2]USG), provided an acute kidney injury risk index. Mean core (intestinal: n = 13, rectal: n = 7) temperature (sucrose-containing: 37.5 +/- 0.1 degree C, sugar-free: 37.5 +/- 0.3 degree C; p = 0.914), peak core temperature (sucrose-containing: 37.8 +/- 0.2 degree C, sugar-free: 37.9 +/- 0.3 degree C; p = 0.398), and percent changes in body mass (sucrose-containing: -0.5 +/- 0.4%, sugar-free: -0.3 +/- 0.6%; p = 0.386) did not differ between groups. [IGFBP7·TIMP-2]USG increased in both groups (time effect: p = 0.025) with no drink (p = 0.675) or interaction (p = 0.715) effects. Peak change [IGFBP7·TIMP-2]USG did not differ between sucrose-containing (median 0.0116 [-0.0012, 0.1760] (ng/mL)2/1000) and sugar-free (median 0.0021 [0.0003, 0.2077] (ng/mL)2/1000; p = 0.796). Sucrose-containing sports drink consumption during simulated occupational heat stress does not modify acute kidney injury risk when compared to sugar free-sport drink consumption. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Heat Stress Disorders Hot Temperature Occupational Health Safety
• Keywords:
  Author Keywords: AKI Dehydration Fructose Heat Stress Hot Environments Hyperthermia Kidney Function Metabolism Polyol-fructokinase Sucrose
• ISSN:
  1715-5320
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Chicago Region [OSHA] ; Indiana ; New York ; New York City Region [OSHA]
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-12
• NIOSHTIC Number:
  nn:20070461
• Citation:
  Appl Physiol Nutr Metab 2025 Jan; 50:1-12
• Contact Point Address:
  Zachary J. Schlader, Department of Kinesiology, Indiana University School of Public Health - Bloomington, Bloomington, IN
• Email:
  zschlade@iu.edu
• CAS Registry Number:
  Sucrose (CAS RN 57-50-1)
• Federal Fiscal Year:
  2025
• Performing Organization:
  Indiana University, Bloomington
• Peer Reviewed:
  True
• Start Date:
  20190901
• Source Full Name:
  Applied Physiology, Nutrition, and Metabolism
• End Date:
  20240831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0f2c9a40f13c8dd69cf7ff2979a082e100df7092955188c00599957412d51e443844f74925096c6c1bdab8f48f362dfef4bc86765aecf6251954ff964c891df8
• Download URL:
  https://stacks.cdc.gov/view/cdc/208664/cdc_208664_DS1.pdf
• File Type:
  [PDF - 1.61 MB ]