Respiratory Diseases Associated with Organic Dust Exposure

Details

• Personal Author:
  De las Vecillas L ; Poole JA ; Quirce S ; Zamora-Sifuentes JL
• Description:
  Organic dusts are complex bioaerosol mixtures comprised of dust and particulate matter of organic origin. These include components from bacteria, fungi, pollen, and viruses to fragments of animals and plants commonplace to several environmental/occupational settings encompassing agriculture/farming, grain processing, waste/recycling, textile, cotton, woodworking, bird breeding, and more. Organic dust exposures are linked to development of chronic bronchitis, chronic obstructive pulmonary disease, asthma, asthma-like syndrome, byssinosis, hypersensitivity pneumonitis, and idiopathic pulmonary fibrosis. Risk factors of disease development include cumulative dust exposure, smoking, atopy, timing/duration, and nutritional factors. The immunopathogenesis predominantly involves Toll-like receptor signaling cascade, T-helper 1/T-helper 17 lymphocyte responses, neutrophil influx, and potentiation of manifestations associated with allergy. The true prevalence of airway disease directly attributed to organic dust, especially in a workplace setting, remains challenging. Diagnostic confirmation can be difficult and complicated by hesitancy from workers to seek medical care, driven by fears of potential labor-related consequence. Clinical respiratory and systemic presentations coupled with allergy testing, lung function patterns of obstructive versus restrictive disease, and radiological characteristics are typically utilized to delineate these various organic dust-associated respiratory diseases. Prevention, risk reduction, and management primarily focus on reducing exposure to the offending dust, managing symptoms, and preventing disease progression. [Description provided by NIOSH]
• Subjects:
  Agriculture Asthma Asthma, Occupational Dust Fibrosis Occupational Exposure Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Author Keywords: Asthma Bioaerosols Bronchitis Chronic Obstructive Pulmonary Disease COPD Hypersensitivity Pneumonitis Obstructive Lung Disease Occupational Occupational Exposure Organic Dust Organic Dusts Particulates Respiratory Diseases

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• ISSN:
  2213-2198
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  12
• Issue:
  8
• NIOSHTIC Number:
  nn:20070002
• Citation:
  J Allergy Clin Immunol Pract 2024 Aug; 12(8):1960-1971
• Contact Point Address:
  Jill A. Poole, MD, Division of Allergy & Immunology, Department of Internal Medicine, University of Nebraska Medical Center, 985990 Nebraska Medical Center, Omaha, NE 68198-5990
• Email:
  japoole@unmc.edu
• Federal Fiscal Year:
  2024
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center
• Peer Reviewed:
  True
• Start Date:
  20210901
• Source Full Name:
  Journal of Allergy and Clinical Immunology: In Practice
• End Date:
  20250831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f303159453ab6d9c3c0f0d76927c76b0fda727d13d4c934f8e9e3802af6c19e71c404474dd18ec9494205f17b957a1551ad2693829290860f4b9c27f1f868437
• Download URL:
  https://stacks.cdc.gov/view/cdc/208313/cdc_208313_DS1.pdf
• File Type:
  [PDF - 406.26 KB ]