Chromium Distribution in an Oropharyngeal Aspiration Model for Hexavalent Chromium in Rats

Details

• Personal Author:
  Croom-Perez TJ ; Hoyle GW ; Kouokam JC ; Liu KJ ; Lu H ; Meaza I ; Specht A ; Speer RM ; Toyoda JH ; Wise JP Jr. ; Wise JP Sr. ; Wise SS ; Young J
• Description:
  Hexavalent chromium [Cr(VI)] is a well-known and widespread environmental contaminant associated with a variety of adverse health effects, in particular lung cancer. The primary route of exposure in humans is through inhalation. Particulate forms of Cr(VI) are the most potent but in vivo studies are difficult. Intratracheal instillation requires highly trained surgical procedures which also limits the number of repeated exposures possible and thus requires high doses. Inhalation studies can deliver lower more chronic doses but are expensive and generate dangerous aerosols. We evaluated an oropharyngeal aspiration exposure route for zinc chromate particles in Wistar rats. Animals were treated once per week for 90 days. We found chromium accumulated in the lungs, blood, and reproductive tissues of all treated animals. Additionally, we found inflammatory indicators in the lung were elevated and circulating lymphocytes had increased chromosomal damage. These results show oropharyngeal aspiration provides a practicable exposure route for chronic and sub-chronic exposures of Cr(VI) particles. [Description provided by NIOSH]
• Subjects:
  Chromium Chromosomes Environmental Pollution Occupational Exposure Occupational Health Particulate Matter Respiratory System Safety
• Keywords:
  Author Keywords: Hexavalent Chromium Chromosome Damage Chronic Exposure Environmental Contamination Inflammation Inhalation Oropharyngeal Aspiration Particulates
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; Kentucky ; New Mexico ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  457
• NIOSHTIC Number:
  nn:20069922
• Citation:
  Toxicol Appl Pharmacol 2022 Dec; 457:116294
• Contact Point Address:
  John Pierce Wise Sr., Professor of Pharmacology and Toxicology, Distinguished University Scholar, Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, 500 S. Preston St., 55A, Room 1422, United States of America
• Email:
  John.Wise@louisville.edu
• CAS Registry Number:
  Chromium(6+) (CAS RN 18540-29-9)
• Federal Fiscal Year:
  2023
• Performing Organization:
  Purdue University
• Peer Reviewed:
  True
• Start Date:
  20210901
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  20220731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7d1efed029173e83e92a33d3805239e1fdb0eafa6bcb7c2f94589956fc3ff0c2795c51bd0a62d63bfa1241f4bbd49bf9bdc1e2ae3df98582fcb7e8454c99e7d9
• Download URL:
  https://stacks.cdc.gov/view/cdc/208244/cdc_208244_DS1.pdf
• File Type:
  [PDF - 1.76 MB ]