Spatial Control of Perilacunar Canalicular Remodeling During Lactation

Details

• Personal Author:
  Acevedo C ; Alliston T ; Nemani M ; Parkinson DY ; Sieverts M ; Yee C
• Description:
  Osteocytes locally remodel their surrounding tissue through perilacunar canalicular remodeling (PLR). During lactation, osteocytes remove minerals to satisfy the metabolic demand, resulting in increased lacunar volume, quantifiable with synchrotron X-ray radiation micro-tomography (SRµCT). Although the effects of lactation on PLR are well-studied, it remains unclear whether PLR occurs uniformly throughout the bone and what mechanisms prevent PLR from undermining bone quality. We used SRµCT imaging to conduct an in-depth spatial analysis of the impact of lactation and osteocyte-intrinsic MMP13 deletion on PLR in murine bone. We found larger lacunae undergoing PLR are located near canals in the mid-cortex or endosteum. We show lactation-induced hypomineralization occurs 14 µm away from lacunar edges, past a hypermineralized barrier. Our findings reveal that osteocyte-intrinsic MMP13 is crucial for lactation-induced PLR near lacunae in the mid-cortex but not for whole-bone resorption. This research highlights the spatial control of PLR on mineral distribution during lactation. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Minerals Occupational Health Safety
• Keywords:
  Bone Structure Breastfeeding Lactation Metabolism Physiology Skeletal System
• ISSN:
  2045-2322
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 8 ; OSHA Region 9 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• NIOSHTIC Number:
  nn:20069820
• Citation:
  Sci Rep 2024 Jun; 14:14655
• Contact Point Address:
  Claire Acevedo, Department of Mechanical Engineering, University of Utah, Salt Lake City, UT, 84112
• Email:
  claire.acevedo@gmail.com
• Federal Fiscal Year:
  2024
• Performing Organization:
  University of Utah
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Scientific Reports
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:903c24ffd8376a951a34cb8e200f2ad79378be68eb0bad15dc87e492236816316d5a364581528ca66c109553615253bf91dba3d555542b8d3e03af2926c481cd
• Download URL:
  https://stacks.cdc.gov/view/cdc/208172/cdc_208172_DS1.pdf
• File Type:
  [PDF - 7.64 MB ]