Creatinine Clearance Is Maintained in a Range of Wet-Bulb Globe Temperatures and Work-Rest Ratios During Simulated Occupational Heat Stress

Details

• Personal Author:
  Baker TB ; Hess HW ; Hostler D ; Johnson BD ; Schlader ZJ ; Tarr ML ; Zoh RS
• Description:
  We tested the hypothesis that compliance with the National Institute for Occupational Safety and Health (NIOSH) heat stress recommendations will prevent reductions in glomerular filtration rate (GFR) across a range of wet-bulb globe temperatures (WBGTs) and work-rest ratios at a fixed work intensity. We also tested the hypothesis that noncompliance would result in a reduction in GFR compared with a work-rest matched compliant trial. Twelve healthy adults completed five trials (four NIOSH compliant and one noncompliant) that consisted of 4 h of exposure to a range of WBGTs. Subjects walked on a treadmill (heat production: approximately 430 W) and work-rest ratios (work/h: 60, 45, 30, and 15 min) were prescribed as a function of WBGT (24 degrees C, 26.5 degrees C, 28.5 degrees C, 30 degrees C, and 36 degrees C), and subjects drank a sport drink ad libitum. Peak core temperature (TC) and percentage change in body weight (% delta BW) were measured. Creatinine clearance measured pre- and postexposure provided a primary marker of GFR. Peak TC did not differ among NIOSH-compliant trials (P = 0.065) but differed between compliant versus noncompliant trials (P < 0.001). % delta BW did not differ among NIOSH-compliant trials (P = 0.131) or between compliant versus noncompliant trials (P = 0.185). Creatinine clearance did not change or differ among compliant trials (P ≥ 0.079). Creatinine clearance did not change or differ between compliant versus noncompliant trials (P ≥ 0.661). Compliance with the NIOSH recommendations maintained GFR. Surprisingly, despite a greater heat strain in a noncompliant trial, GFR was maintained highlighting the potential relative importance of hydration. [Description provided by NIOSH]
• Subjects:
  Body Weight Heat Stress Disorders Hot Temperature Occupational Health Safety Temperature
• Keywords:
  Author Keywords: Exercise Body Weight Glomerular Filtration Rate Heat Stress Kidney Function Physical Exercise Temperature Effects
• ISSN:
  1931-857X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; New York ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  327
• Issue:
  2
• NIOSHTIC Number:
  nn:20069808
• Citation:
  Am J Physiol Renal Physiol 2024 Aug; 327(2):F224-F234
• Contact Point Address:
  Zachary J Schlader, Department of Kinesiology, School of Public Health-Bloomington, Indiana University, Bloomington, Indiana, United States
• Email:
  zschlade@iu.edu
• Federal Fiscal Year:
  2024
• Performing Organization:
  Indiana University, Bloomington
• Peer Reviewed:
  True
• Start Date:
  20190901
• Source Full Name:
  American Journal of Physiology: Renal Physiology
• End Date:
  20240831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:25531c12ea213fdc57707462963c4a24b639249db4f481b9ad42ff4dc5cd6b2380d59830b716030356f0e688f67a4b3801e040641b726a944f377901ec5161ea
• Download URL:
  https://stacks.cdc.gov/view/cdc/208163/cdc_208163_DS1.pdf
• File Type:
  [PDF - 907.85 KB ]