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Micro- and Nanoplastics Concepts for Particle and Fibre Toxicologists

Public Domain


Details

  • Personal Author:
  • Description:
    Micro- and nanoplastic particles (MNP) are omnipresent as either pollution or intentionally used in consumer products, released from packaging or even food. There is an exponential increase in the production of plastics. With the realization of bioaccumulation in humans, toxicity research is quickly expanding. There is a rapid increase in the number of papers published on the potential implications of exposure to MNP which necessitates a call for quality criteria to be applied when doing the research. At present, most papers on MNP describe the effects of commercially available polymer (mostly polystyrene) beads that are typically not the MNP of greatest concern. This is not a fault of the research community, necessarily, as the MNPs to which humans are exposed are usually not available in the quantities needed for toxicological research and innovations are needed to supply environmentally-relevant MNP models. In addition, like we have learned from decades of research with particulate matter and engineered nanomaterials, sample physicochemical characteristics and preparation can have major impacts on the biological responses and interpretation of the research findings. Lastly, MNP dosimetry may pose challenges as (1) we are seeing early evidence that plastics are already in the human body at quite high levels that may be difficult to achieve in acute in vitro studies and (2) plastics are already in the diets fed to preclinical models. This commentary highlights the pitfalls and recommendations for particle and fibre toxicologists that should be considered when performing and disseminating the research. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    1743-8977
  • Document Type:
    Text
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Division:
    HELD - Health Effects Laboratory Division
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    18
  • Volume:
    21
  • NIOSHTIC Number:
    nn:20069475
  • Citation:
    Part Fibre Toxicol 2024 Apr; 21:18
  • Contact Point Address:
    Matthew J. Campen, Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, 87122 Albuquerque, NMMSC09 5360
  • Email:
    MCampen@salud.unm.edu
  • Federal Fiscal Year:
    2024
  • NORA Priority Area:
    Manufacturing
  • Peer Reviewed:
    True
  • Source Full Name:
    Particle and Fibre Toxicology
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:d675edd29f783b667348ffd1079ecc763f8d4c6254199d6784f15aab1717b4aa935d25df1a4649f6d38a76dc4e53c92cdcfbd4e42c1b9e7f027d3609e440df29
  • Download URL:
  • File Type:
    Filetype[PDF - 1.50 MB ]
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