Inflammatory Markers in World Trade Center Workers with Asthma: Associations with Post Traumatic Stress Disorder

Details

• Personal Author:
  Agrawal N ; Ankam J ; Birmingham JM ; Busse PJ ; Federman A ; Gonzalez A ; Markowitz SB ; Wisnivesky JP
• Description:
  Background: Post-traumatic stress disorders (PTSD) is associated with worse asthma outcomes in individuals exposed to the World Trade Center (WTC) site. Research question: Do WTC workers with coexisting PTSD and asthma have a specific inflammatory pattern that underlies the relationship with increased asthma morbidity? Study design and methods: We collected data on a cohort of WTC workers with asthma recruited from the WTC Health Program. Diagnosis of PTSD was ascertained with a Structured Clinical Interview for DSM-5 (Diagnostic and Statistical Manuel of Mental Disorders) and the severity of PTSD symptoms was assessed with the PTSD Checklist 5. We obtained blood and sputum samples to measure cytokines levels in study participants. Results: Of the 232 WTC workers with diagnosis of asthma in the study, 75 (32%) had PTSD. PTSD was significantly associated with worse asthma control (p = 0.002) and increased resource utilization (p = 0.0002). There was no significant association (p>0.05) between most blood or sputum cytokines with PTSD diagnosis or PCL-5 scores both in unadjusted and adjusted analyses. Interpretation: Our results suggest that PTSD is not associated with blood and sputum inflammatory markers in WTC workers with asthma. These findings suggest that other mechanisms likely explain the association between PTSD and asthma control in WTC exposed individuals. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Cohort Studies Immune System Mental Health Nervous System Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Cohort Studies Cytokines Immune Reaction Mental Health Post-traumatic Stress Disorder PTSD World Trade Center WTC
• ISSN:
  1932-6203
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  2
• NIOSHTIC Number:
  nn:20069240
• Citation:
  PLoS One 2024 Feb; 19(2):e0297616
• Contact Point Address:
  Nikita Agrawal, Division of Pulmonary and Critical Care Medicine, Icahn School of Medicine at Mount Sinai, NY, NY, United States of America
• Email:
  nikita.agrawal@mountsinai.org
• Federal Fiscal Year:
  2024
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  PLoS One
• End Date:
  20210831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e7a53e682b986ea2ca110aab373ea1675c0fbc9fb7fea9e72fded44494d940b6fe25d90b0fe7a7fd851b6f540dc52fffa7ac8a15fab810304d1cb038407d78f5
• Download URL:
  https://stacks.cdc.gov/view/cdc/207749/cdc_207749_DS1.pdf
• File Type:
  [PDF - 401.88 KB ]