MnO2 Nanosheet-Carbon Dots Sensing Platform for Sensitive Detection of Organophosphorus Pesticides

Details

• Personal Author:
  Du D ; Li H ; Lin Y ; Song Y ; Su X ; Yan X ; Zhu C
• Description:
  Carbon dots (CDs) combined with a nanomaterial-based quencher has created an innovative way for designing promising sensors. Herein, a novel fluorescent-sensing platform was designed for sensitive detection of organophosphorus pesticides (OPs). The preparation of CDs was based on one-step hydrothermal reaction of 3-aminobenzeneboronic acid. The fluorescence of CDs can be quenched by manganese dioxide (MnO2) nanosheets via the Förster resonance energy transfer (FRET). In the presence of butyrylcholinesterase (BChE) and acetylthiocholine, the enzymatic hydrolysate (thiocholine) can efficiently trigger the decomposition of MnO2 nanosheets, resulting in the recovery of CDs fluorescence. OPs as inhibitors for BChE activity can prevent the generation of thiocholine and decomposition of MnO2 nanosheets, accompanying the fluorescence "turn-off" of the system. So the BChE-ATCh-MnO2-CDs system can be utilized to detect OPs quantitatively based on the fluorescence turn "on-off". Under the optimum conditions, the present FRET-based approach can detect paraoxon ranging from 0.05 to 5 ng mL-1 with a detection limit of 0.015 ng mL-1. Meanwhile, the present strategy also showed a visual color change in a concentration-dependent manner. Thus, the proposed assay can potentially be a candidate for OPs detection. [Description provided by NIOSH]
• Subjects:
  Insecticides Occupational Health Organophosphates Safety
• Keywords:
  Fluorescence Spectrometry Nanomaterials Nanotechnology Organophosphorus Pesticides Pesticides And Agricultural Chemicals Sensors
• ISSN:
  0003-2700
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  90
• Issue:
  4
• NIOSHTIC Number:
  nn:20068963
• Citation:
  Anal Chem 2018 Jan; 90(4):2618-2624
• Contact Point Address:
  Yuehe Lin, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington 99164, United States
• Email:
  yuehe.lin@wsu.edu
• CAS Registry Number:
  Manganese oxide (MnO2) (CAS RN 1313-13-9)
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  Battelle Pacific Northwest Laboratories, Richland, Washington
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  Analytical Chemistry
• End Date:
  20200831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6ebda4918de1ad62c40639b66d68072da98943bd9850ffc339c390734ea6940e0be4b520dbea7ec297f6bb4deca43c8b0a8d61cf1d61c17f7ba3fadf83977f1d
• Download URL:
  https://stacks.cdc.gov/view/cdc/207520/cdc_207520_DS1.pdf
• File Type:
  [PDF - 2.97 MB ]