Differential Developmental Neurotoxicity and Tissue Uptake of the per- and Polyfluoroalkyl Substance Alternatives, GenX and PFBS

Details

• Personal Author:
  Choi YJ ; Freeman JL ; King H ; Lee LS ; Wasel O
• Description:
  Per- and polyfluoroalkyl substances (PFAS) are a class of synthetic chemicals with several applications. Multiple adverse health effects are reported for longer carbon chain (≤C8) PFAS. Shorter carbon chain PFAS, [e.g., hexafluoropropylene oxide dimer acid (HFPO-DA; GenX) and perfluorobutanesulfonic acid (PFBS)] were introduced as alternatives. Past studies indicate that longer-chain PFAS are neurotoxic targeting the dopamine pathway, but it is not known if shorter-chain PFAS act similarly. This study aimed to evaluate developmental neurotoxicity and tissue uptake of GenX and PFBS using the zebrafish (Danio rerio). First, acute toxicity was assessed by measuring LC50 at 120 h postfertilization (hpf). Body burden was determined after embryonic exposure (1-72 hpf) to sublethal concentrations of GenX or PFBS by LC-ESI-MS/MS. Locomotor activity using a visual motor response assay at 120 hpf and dopamine levels at 72 hpf was assessed after embryonic exposure. PFBS was more acutely toxic and bioaccumulative than GenX. GenX and PFBS caused hyperactivity at 120 hpf, but stronger behavioral alterations were observed for PFBS. An increase in whole organism dopamine occurred at 40 ppb of GenX, while a decrease was observed at 400 ppb of PFBS. Differences detected in dopamine for these two PFAS indicate differential mechanisms of developmental neurotoxicity. [Description provided by NIOSH]
• Subjects:
  Behavior Nervous System Occupational Health Safety
• Keywords:
  Author Keywords: Behavior Bioaccumulation Dopamine HFPO-DA Neuromotor Function Neurophysiological Effects Neurotoxic Effects Neurotoxicity Neurotransmitters Per- And Polyfluoroalkyl Substances Perfluoroalkyl Substances Perfluorobutanesulfonic Acid PFAS Polyfluoroalkyl Substances Toxicokinetics

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• ISSN:
  0013-936X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Indiana ; Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  57
• Issue:
  48
• NIOSHTIC Number:
  nn:20068954
• Citation:
  Environ Sci Technol 2023 Dec; 57(48):19274-19284
• Contact Point Address:
  Jennifer L. Freeman, School of Health Sciences, Purdue University, West Lafayette, Indiana 47907, United States
• Email:
  jfreema@purdue.edu
• CAS Registry Number:
  2,3,3,3-Tetrafluoro-2-(1,1,2,2,3,3,3-heptafluoropropoxy)propanoic acid (CAS RN 13252-13-6) ; Perfluorobutanesulfonic acid (CAS RN 375-73-5)
• Federal Fiscal Year:
  2024
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Science and Technology
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0dc1992efe08141d256cc9364e52e695abb888f3b6ca0f7d437ab8f5e9a8ad39e66660086e9f91ee44e54396ceb3f5567427d4630b5df62dba48a64e23380232
• Download URL:
  https://stacks.cdc.gov/view/cdc/207511/cdc_207511_DS1.pdf
• File Type:
  [PDF - 2.15 MB ]