Shiftwork, Long Working Hours and Markers of Inflammation in a National US Population-Based Sample of Employed Black and White Men and Women Aged ≥45 Years

Details

• Personal Author:
  Akinyemiju TF ; Cushman M ; Howard VJ ; MacDonald, Leslie A. ; Velazquez-Kronen, Raquel
• Description:
  Objectives: Work schedule demands contribute to circadian disruption and may influence health via an inflammatory response. We examined the impact of shiftwork and long work hours on inflammation in a national US sample. Methods: Participants included 12 487 employed black and white men and women aged ≥45 years enrolled in the REasons for Geographic and Racial Differences in Stroke Study who completed an occupational questionnaire (2011-2013) and clinical examination (2013-2016). Cross-sectional associations between shiftwork and work hours with log-transformed high-sensitivity C reactive protein (CRP) and white blood cell (WBC) count were examined by multiple linear regression analysis, overall and by race-sex subgroups. Results: Overall, rotating shift workers had higher log-CRP concentration compared with day workers (β=0.09, 95% CI:0.02 to 0.16) and findings for WBC were null. Black women had the highest geometric mean CRP (2.82 mg/L), while white men had the highest WBC (6.35×109/L). White men who worked afternoons had higher log-CRP compared with those who worked days (β=0.20, 95% CI: 0.08 to 0.33). Black men engaged in shiftwork <10 years working ≥55 hours/week had higher log-CRP and log-WBC compared with those working days <55 hours/week (β=0.33, 95% CI: 0.02 to 0.64 and β=0.10, 95% CI: 0.003 to 0.19). Among shift workers, non-retired white women working forward and backward shift rotations had higher log-CRP compared with those working forward only (β=0.49, 95% CI: 0.02 to 0.96). Conclusions: Shift workers had higher inflammatory markers compared with day workers and race-sex disparities should be examined further. These findings highlight a potential biological pathway linking work schedule demands and chronic disease. [Description provided by NIOSH]
• Subjects:
  Immune System Occupational Health Safety Shift Work Schedule
• Keywords:
  Chronic Inflammation Cross Sectional Studies Immune Reaction Long Work Hours Shift Work Work Schedules
• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; North Carolina ; Ohio ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5 ; Vermont
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DFSE - Division of Field Studies and Engineering
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  80
• Issue:
  11
• NIOSHTIC Number:
  nn:20068601
• Citation:
  Occup Environ Med 2023 Nov; 80(11):635-643
• Contact Point Address:
  Dr Raquel Velazquez-Kronen, Field Research Branch, Division of Field Studies and Engineering, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA
• Email:
  ohc0@cdc.gov
• Federal Fiscal Year:
  2024
• Peer Reviewed:
  True
• Source Full Name:
  Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9b4b4d058564c19f9766abeca1ba30bab92a7299d72ce1c0f79166f03a82e036e1aee542c520c6ab0fc3c99150ca0086efeea3d7f8d7ee3d462e20dee1f43702
• Download URL:
  https://stacks.cdc.gov/view/cdc/207205/cdc_207205_DS1.pdf
• File Type:
  [PDF - 283.22 KB ]