Maternal and Neonatal Outcomes of COVID-19 Vaccination During Pregnancy, a Systematic Review and Meta-Analysis

Details

• Personal Author:
  Arroyo A ; Blumrick R ; Brazil G ; Coriell C ; Goetz S ; Govindan M ; Grover S ; King A ; Marchand G ; Masoud AT ; Moberly A ; Moir C ; Parise J ; Proctor A ; Sainz K ; Ulibarri H
• Description:
  Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is associated with increased pregnancy complications. Despite effective vaccination strategies for the general population, the evidence on the safety and efficacy of Coronavirus disease 2019 (COVID-19) vaccinations in pregnancy is limited due to a lack of well-powered studies. The present study compares the maternal, neonatal, and immunological outcomes between vaccinated pregnant and unvaccinated pregnant women using a systematic review and meta-analysis approach. We included 37 studies with a total of 141,107 pregnant women (36.8% vaccinated) spread across all outcomes. Our evidence indicates a higher rate of cesarean section in the 1898 vaccinated pregnant women compared to the 6180 women who did not receive vaccination (OR = 1.20, CI = (1.05, 1.38), P = 0.007, I2 = 45%). Regarding immunological outcomes, the risk of SARS-CoV-2 infection during pregnancy or postpartum was significantly reduced in 6820 vaccinated pregnant women compared to 17,010 unvaccinated pregnant women (OR = 0.25, CI = 0.13-0.48, P < 0.0001, I2 = 61%), as evident from qualitative assessment indicating significantly higher postpartum antibody titers compared to that observed in both unvaccinated mothers and mothers who have recently recovered from a SARS-CoV-2 infection. Our analysis represents high quality evidence showing that COVID-19 vaccination effectively raises antibody titers against SARS-CoV-2. This may confer protection against infection during pregnancy and the postpartum period. In addition to being protective against SARS-CoV-2, the vaccine was associated with decreased odds of preterm delivery. Furthermore, COVID-19 vaccination may also be associated with higher odds of cesarean section. [Description provided by NIOSH]
• Subjects:
  Communicable Diseases Epidemiology Immune System Occupational Health Pregnancy Safety
• Keywords:
  Coronavirus COVID-19 Immunology SARS-CoV-2 Systematic Reviews Vaccines
• ISSN:
  2059-0105
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; Iowa ; OSHA Region 7 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  8
• NIOSHTIC Number:
  nn:20068537
• Citation:
  NPJ Vaccines 2023 Jul; 8:103
• Contact Point Address:
  Greg Marchand, Marchand Institute for Minimally Invasive Surgery, Mesa, AZ, USA
• Email:
  gm@marchandinstitute.org
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  NPJ Vaccines
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1d169e3f60e9d3e699144feeb88596fcd82a2932d1601bf3e679fff83c0ad57f06907f95f5c17674cbe4e1d3524a883eeb1038fe313cb1158412f0af797447de
• Download URL:
  https://stacks.cdc.gov/view/cdc/207148/cdc_207148_DS1.pdf
• File Type:
  [PDF - 1.01 MB ]