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Lower Mortality Risk in APOE4 Carriers with Normal Cognitive Ageing



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  • Personal Author:
  • Description:
    Abnormal cognitive ageing, including dementia, poses serious challenges to health and social systems in ageing populations. As such, characterizing factors associated with abnormal cognitive ageing and developing needed preventive measures are of great importance. The e4 allele of the Apolipoprotein E gene (APOE4) is a well-known genetic risk factor for late-onset Alzheimer's disease. APOE4 carriers are also at elevated risk of cardiovascular diseases which are associated with increased risk of cognitive impairment. On the other hand, APOE4 is known to be associated with reduced risk of multiple common types of cancer-a major age-related disease and leading cause of mortality. We conducted the first-ever study of APOE4's opposing effects on cognitive decline and mortality using competing risk models considering two types of death-death with high-amounts versus low-amounts of autopsy-assessed Alzheimer's neuropathology. We observed that APOE4 was associated with decreased mortality risk in people who died with low amounts of Alzheimer's-type neuropathology, but APOE4 was associated with increased mortality risk in people who died with high amounts of Alzheimer's-type neuropathology, a major risk factor of cognitive impairment. Possible preventive measures of abnormal cognitive ageing are also discussed. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    2045-2322
  • Document Type:
    Text
  • Funding:
    Cooperative Agreement
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    13
  • NIOSHTIC Number:
    nn:20068526
  • Citation:
    Sci Rep 2023 Sep; 13:150889
  • Contact Point Address:
    Yongzhao Shao, Department of Population Health, New York University Grossman School of Medicine, New York, NY, USA
  • Email:
    Yongzhao.Shao@nyulangone.org
  • Federal Fiscal Year:
    2023
  • Performing Organization:
    New York University School of Medicine
  • Peer Reviewed:
    True
  • Start Date:
    20220701
  • Source Full Name:
    Scientific Reports
  • End Date:
    20260630
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:418364a6814ef5309a221e732fadff96a6e3bba601761c0f26f5cb60697eabba52528ee14d2fdea19579888ad145d4cf2b4832625c44980c4cd9cd098b21a980
  • Download URL:
  • File Type:
    Filetype[PDF - 3.68 MB ]
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