Changes in MRI Parameters of Porcine Intervertebral Discs Under Compressive Loading

Details

• Personal Author:
  Fathallah F ; Walton J ; Zhou J ; Fathallah F ; Walton J ; Zhou J
• Description:
  Intervertebral disc (IVD) is a major source of Low Back Pain (LBP). The health and functions of the IVD are determined by the inherent biomechanical properties and their interaction with external loading. Recent advances in quantitative Magnetic Resonance Imaging (MRI) techniques have the potential in detecting loading-induced changes in the biomechanical properties of the IVD. Twenty functional spinal units (FSU) from porcine cervical spines were imaged with a 7T scanner to obtain T1p, T2 and Apparent Diffusion Coefficient (ADC) before and after experiencing compressive loading of 263.27N for 60 minutes. Compressive loading was found to significantly decrease T1p and T2 but not ADC, which indicated that T1p and T2 had the potential to detect changes in the biomechanical properties of the IVD due to external loading. These parameters may provide more sensitivity and specificity to understand the injury mechanism of the IVD and contribute to early diagnosis of IVD degeneration. [Description provided by NIOSH]
• Subjects:
  Animals Biomechanical Phenomena Musculoskeletal System Occupational Health Safety
• Keywords:
  Animal Studies Biomechanical Modeling Biomechanics Low Back Pain Magnetic Resonance Imaging MRI Spinal Cord Disorders
• ISSN:
  1071-1813
• Publisher:
  Human Factors and Ergonomics Society
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Proceedings ; Proceedings
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  62
• Issue:
  1
• NIOSHTIC Number:
  nn:20068498
• Citation:
  Proceedings of the Human Factors and Ergonomics Society 62nd Annual Meeting, October 1-5, 2018, Philadelphia, Pennsylvania. Santa Monica, CA: Human Factors and Ergonomics Society, 2018 Sep; 62(1):929-932
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Agriculture, Forestry and Fishing ; Agriculture, Forestry and Fishing
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Proceedings of the Human Factors and Ergonomics Society 62nd Annual Meeting, October 1-5, 2018, Philadelphia, Pennsylvania
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:210faaba9c26455505492ed2b2d646f668cf1a46de6157e51771ef5f1528dea60b04c133746759541c98635b3b90cb46042593857f3aadf684c7b647edb95e8d
• Download URL:
  https://stacks.cdc.gov/view/cdc/207114/cdc_207114_DS1.pdf
• File Type:
  [PDF - 8.61 MB ]