Urinary 2-Thiothiazolidine-4-carboxylic acid (TTCA) as the major urinary marker of carbon disulfide vapor exposure in rats

Details

• Personal Author:
  Cox, Clinton ; Hee SS ; Lynch DW
• Description:
  The purpose of this study was to assess the effect of carbon- disulfide (75150) exposure on the interrelationships of urinary 2- thiothiazolidine-4-carboxylic-acid (TTCA), thioethers (TE), and iodine-azide (IA). Male Sprague-Dawley-rats were exposed to 50, 150, or 500 parts per million (ppm) carbon-disulfide for 6 hours each day, 5 days a week, over a 6 month period. In selected rats, urine was collected over a period of 8 to 16, 16 to 24, and 24 to 48 hours following the last exposure. The elimination of urinary TTCA followed pseudo first order kinetics. The half time of elimination ranged from 4.9 to 5.5 hours for the 8 to 16 hour collection. In the similar period TE elimination had a range of half lives from 7.9 to 9.1 hours. The half life for TE lengthened after the 16 hour mark to 13.1 hours. For IA responsive compounds the respective half lives at carbon-disulfide concentrations of 50, 150, and 500ppm were 12.6, 6.1, and 4.4 hours. TTCA had the best correlation with carbon- disulfide exposure concentration. The authors conclude that TCAA was the most sensitive, precise, and selective of the urinary markers studied. At low concentrations of carbon-disulfide, IA had the poorest selectivity and TE was intermediately selective. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Laboratories Occupational Exposure Occupational Health Respiratory System Safety Sulfides Urine
• Keywords:
  Biological-monitoring Chronic-exposure Inhalation-studies Laboratory-animals Metabolic-study NIOSH-Author Urinalysis
• ISSN:
  0748-2337
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; California ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  81-92
• Volume:
  12
• Issue:
  1
• NIOSHTIC Number:
  nn:00231256
• Citation:
  Toxicol Ind Health 1996 Jan; 12(1):81-92
• Contact Point Address:
  Shane S. Que Hee, Department of Environmental Health Sciences and UCLA Center for Occupational and Environmental Health, UCLA School of Public Health, 10833 Le Conte Avenue, Los Angeles, CA 90095-1772
• CAS Registry Number:
  Carbon disulfide (CAS RN 75-15-0)
• Federal Fiscal Year:
  1996
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Industrial Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:889e6e5515e2eb5653d7b21086111a97e2110167c9a3743d2f30581e683d3a0748a56d08ebb02d53ef622f3a4368e51f10448e969da9830cf6364405166d171c
• Download URL:
  https://stacks.cdc.gov/view/cdc/205828/cdc_205828_DS1.pdf
• File Type:
  [PDF - 616.94 KB ]