The relationship between bone lead and hemoglobin

Details

• Personal Author:
  Hu H ; Korrick S ; Payton M ; Rotnitzky A ; Watanabe H
• Description:
  A cross sectional investigation was conducted in which blood lead (7439921) and bone lead levels among workers with only moderate lead exposure histories were related to blood pressure and indicators of renal function and hematologic status. The 119 study subjects were members of the construction trade union involved in carpentry, demolition and other construction activities. In-vivo bone lead measurements were made using K-X-ray fluorescence. Blood pressure was measured, and blood samples were analyzed for blood lead, hemoglobin, hematocrit, serum uric-acid, and serum creatinine. Bone lead levels were low and not correlated with either hemoglobin or hematocrit. An increase in patella bone lead levels from the lowest to highest quintile in this study population was associated with a decrease in hemoglobin and hematocrit of 11 grams/liter and 0.03, respectively. The authors conclude that this is the first epidemiological study to suggest that bone lead exerts subclinical toxicity in a population of apparently normal workers with low blood lead levels. [Description provided by NIOSH]
• Subjects:
  Blood Construction Industry Epidemiology Hematologic Tests Lead Lead Poisoning Metals Metals, Heavy Occupational Health Poisoning Risk Assessment Risk Factors Safety Staff Development Urogenital Diseases Urogenital System

  More +
• Keywords:
  Blood-analysis Blood-pressure Body-burden Construction-workers Heavy-metal-poisoning Kidney-damage Lead-poisoning NIOSH-Grant NIOSH-Publication Risk-factors Training

  More +
• ISSN:
  0098-7484
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  272
• Issue:
  19
• NIOSHTIC Number:
  nn:00224457
• Citation:
  JAMA 1994 Nov; 272(19):1512-1517
• Contact Point Address:
  Dr Hu, Channing Laboratory, 180 Longwood Ave, Boston, MA 02115
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  1995
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19770930
• Source Full Name:
  Journal of the American Medical Association
• End Date:
  19940630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:da03702c58532fb7617f6c41c6f1fc3d5dc3e0a5dd27d357255edca2d3dd67ab24c835c3cfe564189e4d7611a3ac1399304f47dbb5e4cee241b57286af403acd
• Download URL:
  https://stacks.cdc.gov/view/cdc/205766/cdc_205766_DS1.pdf
• File Type:
  [PDF - 934.98 KB ]