The effects of ethylene dibromide on semen quality: a comparison of short-term and chronic exposure

Details

• Personal Author:
  Ratcliffe, Jennifer M. ; Schrader, Steven M. ; Turner TW
• Description:
  The effects of exposure to ethylene-dibromide (106934) (EDB) on the male reproductive system were investigated in two occupational field studies. The first was a longitudinal study which involved ten forestry workers exposed to EDB for 6 weeks and six unexposed men. In the second study, 46 EDB exposed papaya workers and 43 unexposed men were followed for 5 years. In the first study, sperm velocity decreased in all exposed workers, and semen volume was decreased in nine of the ten men. Only two unexposed men decreased in sperm velocity and semen volume. In the long term EDB exposed workers, decreases in sperm motility and viability occurred. These results suggested that short term exposure to EDB slowed sperm velocity, but that long term exposure caused immotility and cellular death. Semen pH was also affected, observed to be higher in the exposed men compared to the non exposed men in the long term study. The authors conclude that exposure to the reproductive toxicant EDB may be damaging to the accessory sex glands, with multiple sites of action. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Insecticides Occupational Exposure Occupational Health Safety Spermatogenesis Urogenital Diseases Urogenital System
• Keywords:
  Fertility Humans Long-term-study NIOSH-Author Occupational-exposure Pesticides Reproductive-hazards Reproductive-system-disorders Spermatozoa Toxic-effects
• ISSN:
  0890-6238
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  191-198
• Volume:
  2
• Issue:
  3
• NIOSHTIC Number:
  nn:00185692
• Citation:
  Reprod Toxicol 1988 Jan; 2(3/4):191-198
• CAS Registry Number:
  1,2-Dibromoethane (CAS RN 106-93-4)
• Federal Fiscal Year:
  1988
• Peer Reviewed:
  True
• Source Full Name:
  Reproductive Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:675159e66cc9efade93f156805c119c070560a77c51071147224f49e78666d5421f49b81ca450ac528300653303efc2f1a7288cee9ce7498be7553ea4a00e272
• Download URL:
  https://stacks.cdc.gov/view/cdc/205719/cdc_205719_DS1.pdf
• File Type:
  [PDF - 694.99 KB ]