Subchronic inhalation of triethylamine vapor in Fischer-344 rats: organ system toxicity

Details

• Personal Author:
  Hamlin RD ; Lewis TR ; Lynch DW ; Moorman WJ ; Schueler RL ; Stober P
• Description:
  An investigation was conducted to more fully investigate the subchronic toxicity of inhaled triethylamine (121448) (TEA) in rats. Effects of inhaled TEA on other selected organ systems, including the heart, were also investigated. Weanling caesarean derived Fischer-344-rats were exposed at 25 or 247 parts per million TEA for 6 hours a day, 5 days a week, for 28 weeks. Animals were sacrificed after 32 to 34, 58 to 61, and 125 to 127 days. Exposed rats demonstrated no statistically significant differences compared to the controls in any of the measured indices including treatment related effects on organ weights, hematology, clinical chemistry, or electrocardiographic indices. No evidence was observed of any cardiac muscle degeneration or any changes in electrocardiograms or related clinical chemistry indices. The authors state that the data obtained from this investigation suggests that inhaled TEA, at the concentrations tested, does not induce cardiotoxicity in rats. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Amines Cardiovascular Diseases Cardiovascular System Corrosion Hematologic Tests Laboratories Occupational Health Respiratory System Safety
• Keywords:
  Blood-analysis Cardiovascular-system-disorders Corrosion-inhibitors Inhalation-studies Laboratory-animals NIOSH-Author Organic-vapors
• ISSN:
  0748-2337
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  403-414
• Volume:
  6
• Issue:
  3
• NIOSHTIC Number:
  nn:00197850
• Citation:
  Toxicol Ind Health 1990 May; 6(3-4):403-414
• CAS Registry Number:
  Triethylamine (CAS RN 121-44-8)
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Industrial Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9b6a47554d2a617fdef313a45ca4f129e19461c260413d7f3affee284dd6f83513ec36720403a7b740af91e1071e33957574165e524d57c641507926ef3ad07b
• Download URL:
  https://stacks.cdc.gov/view/cdc/205641/cdc_205641_DS1.pdf
• File Type:
  [PDF - 1.19 MB ]