Silica exposure and autoimmune diseases

Details

• Personal Author:
  Goldsmith DF ; Steenland, Kyle
• Description:
  The association between exposure to silica (14808607) and the development of autoimmune diseases was reviewed. Silica exposure has been linked for many years to several diseases of autoimmune origin including arthritis, systemic sclerosis, and scleroderma. More recently, at least ten studies have demonstrated excesses of autoimmune disorders such as arthritis, systemic lupus, Sjogren's syndrome, and chronic renal disease, among granite workers and gold miners with high levels of silica exposure. The activation of macrophages and the production of cytokines due to contact of quartz with the lung following inhalation resulting in the transport of macrophage bound particles to the lymph nodes and subsequent activation of the immune system, and various humoral responses such as hypergammaglobulinemia and the production of rheumatoid factor and antinuclear antibodies, along with other immune complexes has been proposed as a possible mechanism involved in silica induced autoimmune diseases. [Description provided by NIOSH]
• Subjects:
  Dust Hazardous Substances Immune System Mining Musculoskeletal Diseases Musculoskeletal System Occupational Exposure Occupational Health Safety Silicon Dioxide
• Keywords:
  Autoimmunity Connective-tissue-disorders Immune-reaction Immune-system-disorders Kidney-disorders; Mine-workers Mineral-dusts NIOSH-Author Occupational-exposure Silica-dusts Toxic-effects

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Ohio ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  28
• Issue:
  5
• NIOSHTIC Number:
  nn:00229791
• Citation:
  Am J Ind Med 1995 Nov; 28(5):603-608
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  1996
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4dfd6a124793110f57aaef6eb15bb9899a1d23c73ca12516cf3d839eefa7b90b72537c4e76acfd160afd0a39920dd646807704824e52f07e276843b87d929764
• Download URL:
  https://stacks.cdc.gov/view/cdc/205592/cdc_205592_DS1.pdf
• File Type:
  [PDF - 363.94 KB ]