Quantification of volatile solvents in blood by static headspace analysis

Details

• Personal Author:
  Checkoway, Harvey ; Dills RL ; Kalman DA ; Kent SD
• Description:
  A method was presented for headspace analysis of blood from humans with low level exposure to solvents. Studies performed during the development of the method indicated that the headspace methodology must be optimized specifically for blood, rather than by use of parameters derived from headspace experiments with aqueous media. Procedures used to increase sensitivity in water analyses decreased the sensitivity for blood analyses because of their coagulative effects on blood. For optimum sensitivity and precision, standards and samples must be prepared and manipulated so as to minimize loss of the volatile analytes. Solvents studied in this report included 1,1,1-trichloroethane (71556), toluene (108883), o-xylene (95476), m- xylene (108383), p-xylene (106423), ethylbenzene (100414), styrene (100425), alpha-methylstyrene (98839), and 4-methylstyrene (622979) at concentrations ranging from 0.01 to 1 micrograms/milliliter. The physicochemical properties of the internal standard must be closely matched to those of the analytes for valid quantification with the internal standard method of calibration. The authors were unable to find an internal standard that would be adequate for all compounds investigated. [Description provided by NIOSH]
• Subjects:
  Chemistry Chemistry, Analytic Hematologic Tests Occupational Health Safety Solvents
• Keywords:
  Analytical-chemistry Analytical-methods Biological-monitoring Blood-analysis Chemical-analysis NIOSH-Grant NIOSH-Publication Organic-solvents Solvent-vapors
• ISSN:
  0039-9140
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  365-374
• Volume:
  38
• Issue:
  4
• NIOSHTIC Number:
  nn:00203132
• Citation:
  Talanta 1991 Apr; 38(4):365-374
• Contact Point Address:
  Environmental Health University of Washington Dept/environmental Hlth/sc-34 Seattle, WA 98195
• CAS Registry Number:
  1,1,1-Trichloroethane (CAS RN 71-55-6) ; a-Methylstyrene (CAS RN 98-83-9) ; Ethylbenzene (CAS RN 100-41-4) ; m-Xylene (CAS RN 108-38-3) ; o-Xylene (CAS RN 95-47-6) ; p-Methylstyrene (CAS RN 622-97-9) ; p-Xylene (CAS RN 106-42-3) ; Styrene (CAS RN 100-42-5) ; Toluene (CAS RN 108-88-3)
• Federal Fiscal Year:
  1991
• Performing Organization:
  University of Washington, Seattle, Washington
• Peer Reviewed:
  True
• Start Date:
  19881201
• Source Full Name:
  Talanta
• End Date:
  19921130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2f998f5ff073f7b160025d7f825fbc6a9ccfa026255094e134e4cf1fa63bffe47b7977ac094ed67c3ff5c56ebf025443224d1da7341faada9b909a8cf718943e
• Download URL:
  https://stacks.cdc.gov/view/cdc/205443/cdc_205443_DS1.pdf
• File Type:
  [PDF - 989.66 KB ]