Prednisone pretreatment leads to histaminic airway hyporeactivity soon after resolution of the immediate allergic response

Details

• Personal Author:
  Bernstein DI ; Bernstein IL ; Murlas CG ; Steinberg DR
• Description:
  A group of four subjects, in whom dual phase responses following inhalation of bluegrass allergen had been previously documented, were studied to examine the effect of prednisone pretreatment on the development of the early increase in histamine reactivity which occurs soon after resolution of the immediate response in allergic humans. A second study group included four subjects who had been shown to manifest only isolated immediate responses following bluegrass allergen inhalation. Subjects had baseline histamine airway challenges post allergen and subsequent to prednisone pretreatment. The increase in airway reactivity occurring soon after resolution of the immediate response induced by allergens is inhibited by prednisone. Soon after resolution of the immediate response in both atopic groups, the histaminic reactivity had actually decreased significantly in relation to values determined prior to allergen exposure. The authors suggest that such a change in reactivity in both isolated and dual phase responders may be a result of inflammatory cell accumulation in the airway tissue microvasculature. The authors note that the prednisone effect is not dependent on its potential influence on the influx of inflammatory cells into diseased airways. [Description provided by NIOSH]
• Subjects:
  Asthma Hypersensitivity Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Steroids
• Keywords:
  Airway Resistance Allergic Disorders Allergic Reactions Bronchial Asthma Humans NIOSH Grant NIOSH Publication Pulmonary System Disorders
• ISSN:
  0012-3692
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  314-319
• Volume:
  95
• Issue:
  2
• NIOSHTIC Number:
  nn:00232160
• Citation:
  Chest 1989 Feb; 95(2):314-319
• Contact Point Address:
  Internal Medicine Univ of Tennessee, Memphis 956 Court Avenue Memphis, TN 38163
• Federal Fiscal Year:
  1989
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  True
• Start Date:
  19880301
• Source Full Name:
  Chest
• End Date:
  19920229
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d59570b564de61cab754ad44dcdce25f2731971b0fdcabb72734eaccfe4f5974a74aa9be1515d29898c8b077a694838da9a4ea7ecc7758c29cf49b7eae0a53d6
• Download URL:
  https://stacks.cdc.gov/view/cdc/205388/cdc_205388_DS1.pdf
• File Type:
  [PDF - 1.04 MB ]