Oncogenes and oncoproteins in occupational carcinogenesis

Details

• Personal Author:
  Brandt-Rauf PW
• Description:
  The oncogene theory of carcinogenesis was reviewed and discussed in relation to occupational carcinogenesis. The theory was based on the premise that there are preexisting, normally innocuous genes in the human genome which become inappropriately activated during the process of carcinogenesis, changing them into genes capable of causing the active transformation of cells. Oncogenes may produce their effects through the action of their protein products, called oncoproteins. Oncoproteins include growth factors, membrane receptors, signal transducing G-proteins, protein kinases, and nuclear proteins. The ras oncogene was first identified in acute transforming retroviruses which induced rat sarcomas. Cell culture experimentation resulted in the identification of the p21 protein product which is responsible for the transforming activity of activated ras genes in cells. The neu oncogene was first identified in a model animal system dependent on chemical induction of tumors by alkylating agents such as N-nitroso compounds. It was expected that certain oncogenes will be found to play critical roles in some cases of occupational carcinogenesis as studies in this area continue. [Description provided by NIOSH]
• Subjects:
  Cytotoxins DNA Occupational Health Safety
• Keywords:
  Author Keywords: Ras Cell-transformation Cytotoxic-effects DNA-damage Gene-mutation Genotoxic-effects Neu/C-erbB-2/HER-2 NIOSH-Grant NIOSH-Publication Oncogenesis Oncogenic-agents P18S P21 Protein-chemistry Protein-synthesis

  More +
• ISSN:
  0355-3140
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  27-30
• Volume:
  18
• NIOSHTIC Number:
  nn:00209223
• Citation:
  Scand J Work Environ Health 1992 Feb; 18(Suppl 1):27-30
• Contact Point Address:
  Environmental Sciences Columbia University Sch of PH 60 Haven Avenue/b-1 Level New York, NY 10032
• Federal Fiscal Year:
  1992
• Performing Organization:
  Columbia University New York, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19890715
• Source Full Name:
  Scandinavian Journal of Work, Environment & Health
• Supplement:
  1
• End Date:
  19930114
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b11d6397aeb3beade50aa44e85efdc22a6fddfda84595f2de493db33dc9de2392111835097bfabc2c1988a1477c6a81460349f26cd45b79878332f7a76579035
• Download URL:
  https://stacks.cdc.gov/view/cdc/205282/cdc_205282_DS1.pdf
• File Type:
  [PDF - 2.96 MB ]