Nephropathy in cadmium workers: assessment of risk from airborne occupational exposure to cadmium

Details

• Personal Author:
  Halperin, William E. ; Hannon WH ; Lewis B ; Osorio, Ana Maria ; Schober S ; Thun, Michael J.
• Description:
  Workers exposed to cadmium (7440439) in a metal recovery facility in Colorado were examined to assess the quantitative relation between exposure to the metal, various markers of renal tubular and glomerular dysfunction, and disorders potentially related to cadmium and nephropathy. The target population included all 19 active production workers at the facility and all 27 highly exposed former workers who were alive, residing locally, and reachable by phone. When compared with a referent population, the increased cadmium exposure experienced by these workers caused multiple renal tubular functional abnormalities including reduced reabsorption of beta-2- microglobulin, retinol binding protein, calcium, and phosphate. An increase was also noted in serum creatinine concentration related to cadmium dose which suggested impaired glomerular function. The cadmium workers had higher mean systolic and diastolic blood pressures than did referents. Cadmium dose remained the most important predictor of serum creatinine concentration after controlling for age, blood pressure, body size, and other extraneous factors. When the cumulative cadmium exposure of the worker exceeded 300mg/m3 days, the probability of multiple tubular abnormalities and raised serum creatinine concentration increased sharply. This value corresponds to working for 4.3 years at the current levels of exposure allowed in the United States. [Description provided by NIOSH]
• Subjects:
  Cadmium Cardiovascular System Dust Metals Nervous System Diseases Occupational Exposure Occupational Health Poisoning Safety Urogenital Diseases Urogenital System

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• Keywords:
  Cadmium-compounds Cadmium-poisoning Heart-rate Kidney-damage Metal-dusts Nervous-system-disorders NIOSH-Author Occupational-exposure Renal-toxicity
• ISSN:
  0007-1072
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Georgia ; Maine ; Ohio ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  46
• Issue:
  10
• NIOSHTIC Number:
  nn:00191719
• Citation:
  Br J Ind Med 1989 Oct; 46(10):689-697
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9)
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  True
• Source Full Name:
  British Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1147976c87ffdb69c7e96ff5b03fe759a930693157228c67cc19356ff70fc48613fc4756bc74a5ca71a4b9c4bd729b487897340e50f8ba816b1cc702946f2394
• Download URL:
  https://stacks.cdc.gov/view/cdc/205179/cdc_205179_DS1.pdf
• File Type:
  [PDF - 1.36 MB ]