Methodological considerations relevant to epidemiology studies of silica and lung cancer

Details

• Personal Author:
  Checkoway, Harvey
• Description:
  Methodological factors affecting the interpretation of epidemiological studies examining the relationship between occupational exposure to silica (14808607) and lung cancer were reviewed. Data from three studies of Vermont granite workers, South African gold miners, and California diatomaceous earth mining and processing workers were used to illustrate methodological shortcomings in the quality of exposure assessment, control of confounders such as other workplace exposures and cigarette smoking, and the use of pulmonary fibrosis as a precursor to lung cancer. Sources of bias in epidemiologic research, particularly in studies of occupational exposures and lung cancer, were described and discussed. The author presented several recommendations to improve the quality of epidemiologic studies examining occupational silica exposure and lung cancer risk. [Description provided by NIOSH]
• Subjects:
  Epidemiology Lung Lung Diseases Mining Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Silicon Dioxide Smokers Tobacco Products

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• Keywords:
  Analytical-methods Cigarette-smoking Lung-cancer Mining-industry Occupational-exposure; Pulmonary-system-disorders Risk-factors Silica-dusts Statistical-analysis
• ISSN:
  1047-322X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 9 ; Vermont ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  10
• Issue:
  12
• NIOSHTIC Number:
  nn:00232480
• Citation:
  Appl Occup Environ Hyg 1995 Dec; 10(12):1049-1055
• Contact Point Address:
  Harvey Checkoway, Department of Environmental Health, University of Washington, Box 357234, Seattle, Washington 98195
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  1996
• Performing Organization:
  University of Washington, Seattle, Washington
• Peer Reviewed:
  True
• Start Date:
  19940401
• Source Full Name:
  Applied Occupational and Environmental Hygiene
• End Date:
  19960331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:81ef30ed4ed076b121ce6f4a8564fc65ddf8393b66392a5425208c91d0f5e58fce576f1959bc2d6317436fed25be5ee09d07d3dbd5c47e7b8dac8c47daa62453
• Download URL:
  https://stacks.cdc.gov/view/cdc/205100/cdc_205100_DS1.pdf
• File Type:
  [PDF - 955.33 KB ]