Interpretation of urine results used to assess chemical exposure with emphasis on creatinine adjustments: a review

Details

• Personal Author:
  Boeniger, Mark F. ; Lowry, Larry K. ; Rosenberg J
• Description:
  The urinary elimination of creatinine (60275) and its use as a means to express urine concentrations were reviewed and discussed. A description of renal elimination was presented, and the urinary elimination of creatinine was reviewed. The analytical determination of creatinine in urine using a modified Jaffe reaction was described. Studies have demonstrated good precision using this technique on replicate samples and on procedures performed on different days; however, other studies have shown large differences in the accuracy of results obtained in different laboratories. Factors that have been found to influence the urinary elimination of creatinine include diurnal variations, body mass, age, sex, health status, diet, diuresis, exercise, drug use, alcohol use, tobacco use, and incomplete voiding of the urinary bladder. Limitations in the use of creatinine values to correct urine samples were discussed. Other procedures that can be used to correct urine samples such as body size and mathematical corrections were described. [Description provided by NIOSH]
• Subjects:
  Age Factors Occupational Health Safety Sex Characteristics Urine
• Keywords:
  Age-factors Analytical-methods Biological-monitoring Excretion Mathematical-models NIOSH-Author Sex-factors Urinalysis
• ISSN:
  0002-8894
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Missouri ; Ohio ; OSHA Region 5 ; OSHA Region 7 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  54
• Issue:
  10
• NIOSHTIC Number:
  nn:00217127
• Citation:
  Am Ind Hyg Assoc J 1993 Oct; 54(10):615-627
• CAS Registry Number:
  Creatinine (CAS RN 60-27-5)
• Federal Fiscal Year:
  1994
• Peer Reviewed:
  True
• Source Full Name:
  American Industrial Hygiene Association Journal
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0884320e4812b9c13bd23ab16465571d870e43fcc034485f2c393b6d6e509f3b74558d6d9758de77cf2aeb835bfc01f85a30be56e7b7c2b27acb2d985cbb7a91
• Download URL:
  https://stacks.cdc.gov/view/cdc/204970/cdc_204970_DS1.pdf
• File Type:
  [PDF - 1.46 MB ]