Half-life of polychlorinated biphenyls in occupationally exposed workers

Details

• Personal Author:
  Burse VW ; Hannon WH ; Needham LL ; Phillips DL ; Smith AB ; Steele GK
• Description:
  The changes in polychlorinated-biphenyl (1336363) (PCB) concentrations in humans were followed over an 8 year period in occupationally exposed workers. The group of 228 workers at an electrical equipment manufacturing plant in Bloomington, Indiana was first studied in 1977. Aroclor-1242 (53469219) was used at this site in the production of capacitors from 1959 through 1971. Aroclor-1016 (12674112) was used from 1971 through 1977. PCBs were being phased out of operation at this site in 1977. In August of 1985, 60 of the same workers were examined again. At the time of the second examination, the workers were 32 to 67 years old. Blood samples were collected and analyzed for PCBs. There was a decrease in PCB levels over time. The median half life was 2.5 years for Aroclor-1242 and 4.8 years for Aroclor-1254. However, an inverse relationship was noted between the half life values and initial serum concentrations. The authors suggest that this pattern may be a result of continued low level exposure, variation in the time of exposure, or enzyme induction by PCBs. [Description provided by NIOSH]
• Subjects:
  Electricity Energy Metabolism Hematologic Tests Hydrocarbons Manufacturing And Industrial Facilities Occupational Exposure Occupational Health Polycyclic Aromatic Hydrocarbons Safety
• Keywords:
  Blood-analysis Chlorinated-hydrocarbons Electrical-industry Industrial-factory-workers Metabolic-study NIOSH-Author Occupational-exposure Polycyclic-aromatic-hydrocarbons
• ISSN:
  0003-9896
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  351-354
• Volume:
  44
• Issue:
  6
• NIOSHTIC Number:
  nn:00194286
• Citation:
  Arch Environ Health 1989 Nov; 44(6):351-354
• CAS Registry Number:
  1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3) ; Aroclor 1016 (CAS RN 12674-11-2) ; Aroclor 1242 (CAS RN 53469-21-9)
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  True
• Source Full Name:
  Archives of Environmental Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:054b38947e6c8a9cfed14946af32487be92d2feee8e4468165bfd823a4c528053c8bf00d40859c1a68e900114ddb20eb8749b778c5efc278038328676745888a
• Download URL:
  https://stacks.cdc.gov/view/cdc/204826/cdc_204826_DS1.pdf
• File Type:
  [PDF - 490.87 KB ]