Elevated blood pressure in treated hypertensives with low-level lead accumulation

Details

• Personal Author:
  Becker CE ; Fisher JM ; Holman BL ; Osterloh J ; Sharp DS ; Smith AH
• Description:
  An analysis was conducted to assess the relationship between blood lead (7439921) levels (PbB) and blood pressure (BP) in bus drivers treated for hypertension. The sample group included 51 drivers who appeared to be representative of the target population and who were undergoing treatment for hypertension; 33 with primarily diuretics only and 18 with beta blockers. Concentrations of blood lead among these individuals ranged from 2 to 24 micrograms/deciliter (microg/dl). The adjusted regression coefficients relating systolic BP to PbB were -6.4 and 4.5mmHg/natural log(microg/dl) (mmHg/ln(microg/dl)) for the diuretic and beta blocker groups, respectively. The adjusted coefficients for diastolic BP were 1.11 and 14.3mmHg/ln(microg/dl) for the diuretic and beta blocker groups, respectively. The latter relationship represented an average increment of 12mmHg in diastolic BP over the range of observed blood lead levels in subjects treated with beta blockers. The authors conclude that beta blocker treatment may be less effective in reducing diastolic pressure in individuals with higher blood lead levels. The results suggest an action of lead at PbBs below current standards. [Description provided by NIOSH]
• Subjects:
  Blood Hematologic Tests Lead Lead Poisoning Occupational Health Safety Transportation Vehicle Emissions
• Keywords:
  Blood-analysis Blood-pressure Bus-drivers Exhaust-gases Lead-poisoning Medical-treatment NIOSH-Publication Transportation-workers
• ISSN:
  0003-9896
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  18-22
• Volume:
  44
• Issue:
  1
• NIOSHTIC Number:
  nn:00186777
• Citation:
  Arch Environ Health 1989 Feb; 44(1):18-22
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  1989
• Performing Organization:
  University Of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  19820701
• Source Full Name:
  Archives of Environmental Health
• End Date:
  19940630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d386467c56be570d0895ad216f34ec2a865b248a05c4ff41eca59693b3f2570003846a3608e4f3c54323354ccbdb6edaa7e4c591ba3032905e476067fc6cd568
• Download URL:
  https://stacks.cdc.gov/view/cdc/204584/cdc_204584_DS1.pdf
• File Type:
  [PDF - 573.35 KB ]