Effects of parental occupational exposure to solvents and lead on spontaneous abortion

Details

• Personal Author:
  Anttila A ; Hemminki K ; Kyyronen P ; Lindbohm L ; Sallmen M ; Taskinen H
• Description:
  Finnish studies on the possible relationship of parental occupational exposure to organic solvents or inorganic lead (7439921) to the incidence of spontaneous abortion were reviewed. Four groups of persons were studied: pharmaceutical factory workers, laundry and dry cleaning workers, and men and women biologically monitored for solvent exposure. The pregnancies of the workers or the wives of the male workers were identified from the nationwide database on births and spontaneous abortions treated in hospitals in Finland between 1973 and 1983. The odds ratio of spontaneous abortion for maternal exposure to solvents was increased among the pharmaceutical factory workers and significantly increased among the women monitored for solvents. For the individual solvents, high exposures to methylene-chloride (75092), tetrachloroethylene (127184), and aliphatic hydrocarbons were associated with spontaneous abortion. The odds ratio for toluene (108883) was elevated in a small group of shoe workers. Maternal exposure to lead was not associated with increased incidence of spontaneous abortion. Paternal exposure to organic solvents in general and high exposure to toluene and miscellaneous solvents such as thinners showed increased risk for spontaneous abortion. [Description provided by NIOSH]
• Subjects:
  Metals, Heavy Occupational Exposure Occupational Health Pharmacies Safety Solvents Urogenital Diseases Urogenital System
• Keywords:
  Dry-cleaning-industry Dry-cleaning-solvents Heavy-metals NIOSH-Grant NIOSH-Publication Occupational-exposure Pharmaceutical-industry Reproductive-hazards Reproductive-system-disorders Solvent-vapors
• ISSN:
  0355-3140
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  37-39
• Volume:
  18
• NIOSHTIC Number:
  nn:00209507
• Citation:
  Scand J Work Environ Health 1992 Jun; 18(Suppl 2):37-39
• Contact Point Address:
  Dr ML Lindbohm , Institute of Occupational Health, Topeliuksenkatu41 a A, SF-00250 Helsinki, Finland
• CAS Registry Number:
  Dichloromethane (CAS RN 75-09-2) ; Lead (CAS RN 7439-92-1) ; Tetrachloroethylene (CAS RN 127-18-4) ; Toluene (CAS RN 108-88-3)
• Federal Fiscal Year:
  1992
• NORA Priority Area:
  Reproductive System Disorders
• Performing Organization:
  Institute of Occupational Health, Helsinki, Finland
• Peer Reviewed:
  True
• Start Date:
  19840401
• Source Full Name:
  Scandinavian Journal of Work, Environment & Health
• Supplement:
  2
• End Date:
  19870331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:eb041ae12aefe1346a2df59933bb02e6f3217a9b1692bad234700744caae025704ddfcb104adae6e77f7e65c2535fd7c286ba7ae24127a9798c6cfb7c25228f9
• Download URL:
  https://stacks.cdc.gov/view/cdc/204563/cdc_204563_DS1.pdf
• File Type:
  [PDF - 1.77 MB ]