Drake chemical workers' health registry study: I. Notification and medical surveillance of a group of workers at high risk of developing bladder cancer

Details

• Personal Author:
  Callahan C ; Fox J ; Hemstreet G ; Leviton LC ; Logue JN ; Marsh GM ; Pavlock D ; Schulte P ; Talbott EO
• Description:
  An overview was presented of the Drake Health Registry Study (DHRS), which was initiated in 1986 because of probable past exposures of Drake Chemical Company workers to the potent bladder carcinogen, beta-naphthylamine (91598) (BNA). The DHRS had five primary objectives: identify former workers and determine vital status; notify, enroll and maintain compliance among as many living cohort workers as possible; establish and maintain a bladder cancer medical surveillance program; evaluate notification and surveillance programs; evaluate bladder cancer risk and total and cause specific cohort mortality risks. Medical screening included standard urinalysis, Papanicolaou urine cytology and quantitative fluorescence image analysis. Free diagnostic evaluation was available following a positive screening test. After 40 months, the cohort comprised 408 persons (6% female), 42 of them presumed deceased. A total of 334 were notified and 81% were current participants. Distribution of registrants by risk group was 72.1% low, 7.3% medium and 20.6% high. Of 254 persons completing at least initial screening, 27 were eligible for and 18 underwent diagnostic evaluation. No invasive bladder tumors were found, but two cases of moderate to severe dysplasia were diagnosed after third screenings. Six male cohort workers were identified as having bladder cancer. Three were identified by cause of death. Latencies between dates of hire and diagnosis were 9 to 26 (average 19) years. For 35 cohort deaths analyzed, standardized mortality ratios were significantly increased for all causes, all cancers, bladder and other urinary cancer (20 to 30 fold excess) and liver cirrhosis. The authors conclude that six to ten new bladder cancer cases among the cohort are likely over the next 20 years. [Description provided by NIOSH]
• Subjects:
  Amines Manufacturing And Industrial Facilities Morbidity Mortality Neoplasms Occupational Exposure Occupational Health Polycyclic Aromatic Hydrocarbons Safety Surveys And Questionnaires Urogenital Diseases Urogenital System

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• Keywords:
  Aromatic-hydrocarbons Bladder-cancer Chemical-industry-workers Chemical-manufacturing-industry Medical-screening Medical-surveys Morbidity-rates Mortality-rates NIOSH-Author Occupational-exposure Surveillance-programs

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  291-301
• Volume:
  19
• Issue:
  3
• NIOSHTIC Number:
  nn:00199846
• Citation:
  Am J Ind Med 1991 Mar; 19(3):291-301
• CAS Registry Number:
  2-Naphthylamine (CAS RN 91-59-8)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:604b096d2cfff446247803c6089d7f7384e24637d65ab7a1b5a798778d027b73d525efecbb1e68ff5c54405c1bde5df0427dd86c6b3b3f67af78d21343273e09
• Download URL:
  https://stacks.cdc.gov/view/cdc/204516/cdc_204516_DS1.pdf
• File Type:
  [PDF - 732.16 KB ]