Distribution and reactivity of inhaled 14C-labeled toluene diisocyanate (TDI) in rats

Details

• Personal Author:
  Alarie Y ; Brown WE ; Kennedy AL ; Stock MF ; Wilson TR ; Alarie Y ; Brown WE ; Kennedy AL ; Stock MF ; Wilson TR
• Description:
  The biochemical events following inhalation exposure to toluene- diisocyanate (584849) (TDI) in a rat model were characterized to aid the interpretation of the carcinogenic risk. Male Fischer-344-rats were exposed head only to vapors of TDI at exposure levels of 0.026 to 0.821 parts per million (ppm) for 4 hours. All tissues studied showed detectable quantities of radioactivity with the airways, gastrointestinal system and blood having the highest levels which increased with exposure concentration. The concentration in the bloodstream after exposure was linear with respect to dose. Most of the label associated with the blood was recovered in the plasma, and of this, 97 to 100% of the carbon-14 existed in the form of biomolecular conjugates. Stomach content analysis indicated that the majority of the label was also associated with high molecular weight species. Over the vapor exposure and time tested, the authors concluded that conjugation was the predominant reaction and that free toluenediamine (25376458) (TDA) was not a primary in-vivo reaction product under these conditions. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Hematologic Tests Isocyanates Laboratories Lung Occupational Health Respiratory System Safety
• Keywords:
  Blood-analysis Body-burden Dose-response Grants-other Inhalation-studies Laboratory-animals Lung-irritants Metabolic-study NIOSH-Grant NIOSH-Publication Tissue-distribution

  More +
• ISSN:
  0340-5761
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  434-443
• Volume:
  68
• Issue:
  7
• NIOSHTIC Number:
  nn:00221908
• Citation:
  Arch Toxicol 1994 Jul; 68(7):434-443
• Contact Point Address:
  Biological Sciences Carnegie-Mellon University 4400 Fifth Ave Pittsburgh, PA 15213
• CAS Registry Number:
  ar-Methylbenzenediamine (CAS RN 25376-45-8) ; Toluene 2,4-diisocyanate (CAS RN 584-84-9) ; ar-Methylbenzenediamine (CAS RN 25376-45-8) ; Toluene 2,4-diisocyanate (CAS RN 584-84-9)
• Federal Fiscal Year:
  1994
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other ; Other Occupational Concerns ; Grants Other
• Performing Organization:
  Carnegie-Mellon University, Pittsburgh, Pennsylvania
• Peer Reviewed:
  True
• Start Date:
  19851201
• Source Full Name:
  Archives of Toxicology
• End Date:
  19930630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1a34d90f7ac0d603387e54f058374d9892af0cf6ceef335acf0a79645478a6e10b3ec17dd3e19ce29076c1d1fb80a9d5c1dfbf263cfadd0473911296c36e902d
• Download URL:
  https://stacks.cdc.gov/view/cdc/204508/cdc_204508_DS1.pdf
• File Type:
  [PDF - 1.37 MB ]