A New Public Health Tool for Risk Assessment of Abnormal Glucose Levels

Details

• Journal Article:
  Preventing Chronic Disease (PCD)
• Personal Author:
  He, Guozhong ; Sentell, Tetine ; Schillinger, Dean
• Description:
  Introduction ; Self-reported prediabetes and diabetes rates underestimate true prevalence, but mass laboratory screening is generally impractical for risk assessment and surveillance. We developed the Abnormal Glucose Risk Assessment-6 (AGRA-6) tool to address this problem. ; Methods ; Self-report data were obtained from the 1,887 adults (18 years or older) in the National Health and Nutrition Examination Survey (NHANES) 2005-2006 with fasting plasma glucose and oral glucose tolerance tests. We created AGRA-6 models by using logistic regression. Performance was validated with NHANES 2005-2006 data by using leave-1-out cross-validation. Standard performance characteristics (sensitivity, specificity, predictive values, area under receiver-operating characteristic curves) were assessed, as was the potential efficiency of the models to reduce laboratory testing in screening efforts. ; Results ; Performance was good for all models under testing conditions. Use of the AGRA-6 in screening efforts could reduce laboratory testing by at least 30% when sensitivity is maximized and at least 52% when sensitivity and specificity are balanced. ; Conclusion ; The AGRA-6 appears to be an effective, feasible tool that uses self-reported data compatible with the Behavioral Risk Factor Surveillance System to assess population-level prevalence, identify abnormal glucose levels, optimize screening efforts, and focus interventions to reduce the prevalence of abnormal glucose levels.
• Subjects:
  • Original Research
  • Adolescent
  • Adult
  • Blood Glucose
  • Diabetes Mellitus
  • Humans
  • Models, Biological
  • Nutrition Surveys
  • Risk Factors
  • Young Adult
• Source:
  Prev Chronic Dis. 7(2).
• ISSN:
  1545-1151
• Pubmed ID:
  20158962
• Pubmed Central ID:
  PMC2831788
• Document Type:
  Journal Article
• Funding:
  3U32DP922744-05W1/DP/NCCDPHP CDC HHS/United States ; UL1 RR024131/RR/NCRR NIH HHS/United States
• Volume:
  7
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/20443/cdc_20443_DS1.pdf
• File Type:
  [PDF - 463.10 KB]
• Collection(s):
  Preventing Chronic Disease
• Main Document Checksum:
  urn:sha-512:c64d46dc442f933557a05560989e7f39a218232f88277c4829ec3928561f30e7e3358c7b2ba8c81d63a38df95c84c37396b546877354f2e93a3a0a78ff05a57a