Coinhibition of viral interferon induction by benzo[a]pyrene in association with occupation-related particles

Details

• Personal Author:
  Booth JA ; Flowers L ; Hahon N
• Description:
  The in-vitro conditions under which coinhibition of viral interferon induction occurred when mammalian cell monolayers were exposed to bioactivated benzo(a)pyrene (50328) (BaP) in conjunction with representative particles of coal, asbestos (1332214), metals, and silicates were investigated. The Rhesus-monkey kidney cell line LLC- MK2 was used for induction and the Chang human conjunctival cell line clone 1-5c-4 was used for assay of interferon. Ao/PR/9/34 influenza and parainfluenza (Sendai) viruses were used for interferon induction and assay. BaP itself had no adverse effect on the induction process. However, when cell cultures were pretreated with BaP that was bioactivated by rat liver S9 homogenate, from 52% to 65% inhibition of interferon induction occurred. An 83% inhibition of induction occurred when BaP was incorporated with coal particles. When metals were individually mixed with bioactivated BaP, coinhibition of cellular interferon synthesis was also noted. Coinhibition of interferon induction by silicates and bioactivated BaP was not noted. The findings affirmed that enzymatically activated BaP in combination with different particles, the majority of which were occupationally related, acts to coinhibit a biologic defense mechanism, the induction phase of the interferon system. [Description provided by NIOSH]
• Subjects:
  Asbestos Coal Dust Environmental Pollution Hydrocarbons Inorganic Chemicals Metals Occupational Health Polycyclic Aromatic Hydrocarbons Pyrenes Safety Silicon Dioxide

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• Keywords:
  Asbestos-fibers Coal-dust Environmental-contamination Mammalian-cells Metal-dusts Mineral-dusts NIOSH-Author Polycyclic-aromatic-hydrocarbons Silica-dusts
• ISSN:
  0013-9351
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  ALOSH - Appalachian Laboratory for Occupational Safety and Health
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  83-98
• Volume:
  52
• Issue:
  1
• NIOSHTIC Number:
  nn:00195801
• Citation:
  Environ Res 1990 Jun; 52(1):83-98
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Benzo[a]pyrene (CAS RN 50-32-8)
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:725cc73f0ae1503294b2ddcf788d96a49fd6633b213f1f4c8617890033ca313b890240db665f3279bcf4683174670e3b871474b5a64e45c3fbb8aac3773b2080
• Download URL:
  https://stacks.cdc.gov/view/cdc/204349/cdc_204349_DS1.pdf
• File Type:
  [PDF - 989.81 KB ]