Calculating concentration of inhaled radiolabeled particles from external gamma counting: external counting efficiency and attenuation coefficient of thorax

Details

• Personal Author:
  Bergofsky EH ; Foster WM ; Langenback EG
• Description:
  A direct method was used to determine the amount and distribution of a radionuclide in the lungs of five Q-fever negative, mixed breed female sheep between 2 and 4 years of age. Using a series of noninvasive gamma scintillation camera images and postmortem dissections, the exact amount of radionuclide in the form of insoluble carbonized polystyrene particles tagged with cobalt-57 (13981505) was determined. The lungs of the sheep were inflated with one breath, 1 liter, of aerosol each minute for 60 to 90 minutes. Each of these breaths was held for 6 seconds. Measurements made on different sheep at various radionuclide concentrations in the lung have yielded a curve converting counts per minute acquired on the gamma scintillation camera to actual microcuries or particles in the lung of the intact sheep. This relationship permitted the calculation of the external radionuclide counting efficiency and the attenuation of the emitted gamma rays by the chest wall. This has made it possible to standardize a number of variable parameters and quantitate radionuclide or particle dose in the lungs, allowing an accurate evaluation of uptake and change of radionuclides. The results of the study suggest that the data may be extrapolated to humans, but additional experimental support would be needed. [Description provided by NIOSH]
• Subjects:
  Animals Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Analytical Instruments Animal Studies Inhalation Studies Lung Tissue NIOSH Grant NIOSH Publication Pulmonary System Pulmonary System Disorders Radionuclides Tissue Distribution
• ISSN:
  0098-4108
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  139-152
• Volume:
  27
• Issue:
  1
• NIOSHTIC Number:
  nn:00188810
• Citation:
  J Toxicol Environ Health 1989 May; 27(1):139-152
• Contact Point Address:
  Medicine Suny at Stony Brook Hsc, T-17, Room 040, Stony Brook, NY 11794
• CAS Registry Number:
  Cobalt-57 (CAS RN 13981-50-5)
• Federal Fiscal Year:
  1989
• Performing Organization:
  State University New York Stony Brook, Stony Brook, New York
• Peer Reviewed:
  True
• Start Date:
  19870101
• Source Full Name:
  Journal of Toxicology and Environmental Health
• End Date:
  19960131
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:39e04417665dcb03109a230239f5073322b3ca000851c8305c3c42f009ef9fae681b75a864e54b8bbcff3d9e8a8fd39ac002d860dc6748ed3eb9a3f5321d3ebf
• Download URL:
  https://stacks.cdc.gov/view/cdc/204272/cdc_204272_DS1.pdf
• File Type:
  [PDF - 882.71 KB ]