Behavioral teratology investigation of tertiary-butanol administered by inhalation to rats

Details

• Personal Author:
  Brightwell WS ; Khan A ; Krieg EF Jr. ; Massari VJ ; Nelson BK ; Shaw, Peter B.
• Description:
  A study was conducted of physical and behavioral fetal side effects following exposure of pregnant Sprague-Dawley-rats to tertiary- butanol (75650). Tertiary-butanol was administered by inhalation at concentration levels of 12,000 and 6,000mg/m3 to pregnant female rats throughout their gestation period. Exposures were also made to adult male rats subsequently mated to control females. The offspring were treated for neuromotor coordination, activity, and learning. Brains from ten offspring per exposure group were dissected and assayed for protein and the neurotransmitter acetylcholine, dopamine, norepinephrine, serotonin, met-enkephalin, B-endorphin, and substance-P. Maternal toxicity was apparent, but only limited behavioral or neurochemical effects were noted in the offspring on tests conducted through 90 days of age. The authors conclude that exposure to tertiary-butanol does not appear to produce remarkable behavioral or neurochemical deviations in offspring at the concentrations tested. [Description provided by NIOSH]
• Subjects:
  Laboratories Occupational Health Respiratory System Safety Solvents Teratogenesis
• Keywords:
  Author Keywords: Alcohols Behavioral Teratology Developmental-disorders Developmental Neurotoxicology Fetal Alcohol Syndrome Inhalation-studies Laboratory-animals Organic-solvents Prenatal-exposure Solvent-vapors T-butanol T-butyl Alcohol Tertiary Alcohols

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• ISSN:
  0970-3926
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-7
• Volume:
  4
• Issue:
  1
• NIOSHTIC Number:
  nn:00232607
• Citation:
  Pharmacopsychoecologia 1991 Jan; 4(1-2):1-7
• Contact Point Address:
  B.K.Nelson, National Institute for Occupational Safety and Health, C-24, Division of Biomedical and Behavioral Science, 4676 Columbia Parkway, Cincinnati, OH 45226, U.S.A.
• CAS Registry Number:
  tert-Butanol (CAS RN 75-65-0)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  True
• Source Full Name:
  Pharmacopsychoecologia
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9090b798a0306061ac498598eb36dfeffee7c44dd0188ed1d398e144cee9e692c892d9d8cd5f312f89dda818e875161e061466f8fec5d5f5cd861f440c1e1082
• Download URL:
  https://stacks.cdc.gov/view/cdc/204226/cdc_204226_DS1.pdf
• File Type:
  [PDF - 1.18 MB ]