Age specific interactions between smoking and radon among United States uranium miners

Details

• Personal Author:
  Steenland, Kyle
• Description:
  The Hornung and Meinhardt analyses was reexamined to determine age specific interactions between smoking and radon (10043922) exposures in uranium miners working in the United States. Rates for lung cancer among never smoking United States veterans (R0), for ever smoking United States veterans (R1), for never smoking miners exposed to radon (R2), and for ever smoking miners (R12) were compared. The predicted death rates from lung cancer for the R12 category were compared under the additive and multiplicative models. The observed rates were intermediate between those of these two models. The multiplicative model fit the data more closely than the additive at the youngest and oldest age categories. The author notes that the data are limited by small numbers and lack of quantitative data on smoking and exposure to radon daughters for the development of the rate ratios. In this study there were only 14 deaths due to lung cancer among miners who never smoked. The author suggests that perhaps an even greater difficulty or limitation is the lack of understanding of the underlying mechanisms affecting rates at a biological level in that the mechanism by which either smoking or radon cause lung cancer is not totally clear. [Description provided by NIOSH]
• Subjects:
  Age Factors Carcinogens Epidemiology Lung Lung Diseases Mining Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smokers Tobacco Products Uranium

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• Keywords:
  Age-factors Cancer-rates Cigarette-smoking Lung-cancer Mining-industry NIOSH-Author Respiratory-system-disorders Risk-factors Underground-miners Uranium-mining
• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  192-194
• Volume:
  51
• Issue:
  3
• NIOSHTIC Number:
  nn:00219772
• Citation:
  Occup Environ Med 1994 Mar; 51(3):192-194
• CAS Registry Number:
  Radon (CAS RN 10043-92-2)
• Federal Fiscal Year:
  1994
• Peer Reviewed:
  True
• Source Full Name:
  Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e3fb37b80ccb9ff1b5c5639163f4273243be22ff41f7a7f616b24ef0f560d30baa7e8082dc1864c0ccfb013d542449f5c814224cd29ddedfbd487a3bb72c75a0
• Download URL:
  https://stacks.cdc.gov/view/cdc/204094/cdc_204094_DS1.pdf
• File Type:
  [PDF - 546.49 KB ]