Absence of Formic Acid Accumulation in Urine Following Five Days of Methanol Exposure

Details

• Personal Author:
  D'Arcy JB ; Franzblau, Alfred ; Lee EW ; Levine SP ; Santrock J ; Schreck RM
• Description:
  Accumulation of formic-acid (64186) in the urine following exposure to methanol (67561) was studied. Human subjects were exposed to methanol vapor 7 hours per day for 5 days and urinary methanol and formic-acid levels were monitored before and after each exposure. The mean methanol exposure level was 200.9 parts per million (ppm) over the study period with an 8 hour time weighted average methanol exposure of 176ppm for the week. Increases in mean urinary methanol concentrations were seen at the end of each daily exposure session but these returned to baseline values after 16 hours. No changes were seen in the levels of urinary formic-acid in morning samples over the study period. The authors conclude that urinary formic- acid does not accumulate during 5 days of exposure to methanol at levels approaching the maximal permissible exposure limit and that measurement of urinary formic-acid 16 hours after exposure is not useful for identifying methanol exposure on the preceding day. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Occupational Exposure Occupational Health Respiratory System Safety Solvents
• Keywords:
  Alcohols Biological-monitoring Excretion Grants-other Inhalation-studies Metabolism NIOSH-Grant NIOSH-Publication Occupational-exposure Organic-solvents
• ISSN:
  1047-322X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  7 pdf pages
• Volume:
  8
• Issue:
  10
• NIOSHTIC Number:
  nn:00216957
• Citation:
  Appl Occup Environ Hyg 1993 Oct; 8(10):883-888
• CAS Registry Number:
  Formic acid (CAS RN 64-18-6) ; Methanol (CAS RN 67-56-1)
• Federal Fiscal Year:
  1994
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  University of Michigan at Ann Arbor, Ann Arbor, Michigan
• Peer Reviewed:
  True
• Start Date:
  19890901
• End Date:
  19990929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:770db8c6fdf960b3b32129f3e875efbb2183b87b87a2c066c6eeadd408b9da87b50ed1510370c0e41c9a31c6858af64db7e7b2fb742ccda143089c313d08ba3b
• Download URL:
  https://stacks.cdc.gov/view/cdc/204063/cdc_204063_DS1.pdf
• File Type:
  [PDF - 796.65 KB ]