A review of the gastrointestinal effects from exposure to substances contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Details

• Personal Author:
  Calvert, Geoffrey M. ; Fingerhut, Marilyn A. ; Halperin, William E. ; Sweeney M
• Description:
  The association between gastrointestinal effects and 2,3,7,8- tetrachloro-p-dioxin (1746016) (TCDD) exposure were reviewed by analyzing epidemiological studies. Two separate cross sectional population studies revealed statistically significant increases in self reported ulcers in subjects exposed to substances contaminated with TCDD. Conversely, a survey of US Air Force Ranch Hands did not find an increase of gastrointestinal disorders in individuals exposed to TCDD. NIOSH conducted a cross sectional study of occupational exposure to TCDD in workers employed in chemical plants. These groups of workers were exposed to sodium- trichlorophenol (1320792), 2,4,5-trichlorophenoxyacetic-ester, or hexachlorophene (70304). Worker interviews and serum TCDD levels indicated that these subjects had high exposure to TCDD. Data from this study were used to assess the association between TCDD exposure and gastrointestinal disorders. The authors conclude that the effects of TCDD exposure on the liver and gastrointestinal system have not been consistently supported by epidemiological studies. [Description provided by NIOSH]
• Subjects:
  Digestive System Digestive System Diseases Epidemiology Hazardous Substances Liver Occupational Exposure Occupational Health Safety
• Keywords:
  Gastrointestinal-system-disorders Hepatotoxicity Humans NIOSH-Author Occupational-exposure Polychlorinated-aromatic-hydrocarbons Toxic-effects
• ISSN:
  0045-6535
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  243-246
• Volume:
  25
• Issue:
  1
• NIOSHTIC Number:
  nn:00210165
• Citation:
  Chemosphere 1992 Jul; 25(1-2):243-246
• CAS Registry Number:
  2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6) ; Hexachlorophene (CAS RN 70-30-4) ; Phenol, trichloro-, sodium salt (1:1) (CAS RN 1320-79-2)
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  True
• Source Full Name:
  Chemosphere
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:afdac977424bd6fc6a326f0ba5bebe478febb808135167a4694f398cf1f519cd8f4c027ef98c341ccfa28202659c61120e6a9af739cda2b0f224359f760dd31f
• Download URL:
  https://stacks.cdc.gov/view/cdc/204050/cdc_204050_DS1.pdf
• File Type:
  [PDF - 161.42 KB ]