A protocol for bladder cancer screening and medical surveillance among high-risk groups: the Drake health registry experience

Details

• Personal Author:
  Callahan C ; Hemstreet G ; Leviton LC ; Marsh GM ; Pavlock D ; Talbott EO
• Description:
  A description was provided of the development of a clinical protocol currently in use by the Drake Health Registry Study (DHRS). The DHRS was established to screen persons at high risk of developing bladder cancer due to possible occupational exposure to the bladder carcinogen, beta-naphthylamine (91598) (BNA). The Drake Chemical Company operated in Lock Haven, Pennsylvania from 1940 until 1981, at which time the site was designated a hazardous waste site. This was one of the few sites in the United States where BNA was manufactured. A total of 408 former employees has been identified. Of these, 42 died before notification of the investigation. Of the 366 eligible for the screening program, 162 have registered. Eligible employees were provided a battery of screening tests based on a voided urine specimen. The current protocol consists of a two tiered screening schedule and has been utilized successfully for 15 months. Of the 26 results to date, most were based on abnormal Papanicolaou cytology and or quantitative fluorescence image analysis. Bladder abnormalities were cited among most of the 18 study members who underwent diagnostic evaluation, including chronic cystitis, inflammation, hyperplasia, and dysplasia. The authors concluded that the screening program is detecting very early changes in a relatively young cohort and that these persons must be monitored over a number of years to ensure adequate medical surveillance. [Description provided by NIOSH]
• Subjects:
  Manufacturing And Industrial Facilities Neoplasms Occupational Exposure Occupational Health Safety Urogenital Diseases Urogenital System
• Keywords:
  Bladder-cancer Bladder-disorders Cancer-rates Chemical-industry-workers Chemical-manufacturing-industry JOCMA7 Medical-screening NIOSH-Grant NIOSH-Publication Occupational-exposure Screening-methods Worker-health

  More +
• ISSN:
  0096-1736
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Oklahoma ; OSHA Region 3 ; OSHA Region 6 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  32
• Issue:
  9
• NIOSHTIC Number:
  nn:00195439
• Citation:
  J Occup Med 1990 Sep; 32(9):881-886
• Contact Point Address:
  Urology University of Oklahoma Dept of Urology, PO Box 26901 Oklahoma City, OK 73190
• CAS Registry Number:
  2-Naphthylamine (CAS RN 91-59-8)
• Federal Fiscal Year:
  1990
• Performing Organization:
  University of Oklahoma Hlth Sciences Ctr, Oklahoma City, Oklahoma
• Peer Reviewed:
  True
• Start Date:
  19890930
• Source Full Name:
  Journal of Occupational Medicine
• End Date:
  19990430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:10b2d515b05d0485f85da07de3b3319d1dc10edcabfb8733b7f6724ae674ae3386002030a6924a84941ed5c17e615124ca2cae794aa068ed15794a62cd20dd38
• Download URL:
  https://stacks.cdc.gov/view/cdc/204038/cdc_204038_DS1.pdf
• File Type:
  [PDF - 537.30 KB ]