A meta-analysis of colorectal cancer and asbestos exposure

Details

• Personal Author:
  Garabrant, David H. ; Gillespie BW ; Homa DM
• Description:
  A meta analysis of asbestos (1332214) exposure and colorectal cancer mortality was presented in which asbestos type and dust levels were investigated as direct estimators of asbestos exposure. Lung cancer mortality and the proportion of deaths due to mesothelioma were investigated as proxy estimators of asbestos exposure. Published reports of 20 asbestos exposed cohorts formed the basis for this study. An elevated standard mortality ratio (SMR) was determined in cohorts exposed to amphibole asbestos but not in cohorts exposed to serpentine (79617962) asbestos fibers or in cohorts exposed to both serpentine and amphibole asbestos. Cohorts which had a lung cancer standard mortality ratio greater than 2.00 had a summary SMR of 1.51 and cohorts in which more than 1% of all deaths were attributed to mesothelioma had a summary SMR of 1.24. No clear correlation was found between lung cancer mortality and colorectal cancer mortality after stratifying the cohorts based on mortality due to all cancers excluding those known or suspected to be associated with asbestos exposure. There was a possibility noted that amphibole asbestos exposure may be associated with colorectal cancer, but these findings may reflect an artifact of miscertification of the cause of death. [Description provided by NIOSH]
• Subjects:
  Asbestos Digestive System Digestive System Diseases Epidemiology Inorganic Chemicals Mortality Neoplasms Occupational Health Particulate Matter Respiratory Tract Diseases Risk Assessment Risk Factors Safety Staff Development

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• Keywords:
  Asbestos-fibers Author Keywords: Asbestos Cancer-rates Colonic Neoplasms Fibrous-bodies Gastrointestinal-system-disorders Meta-analysis Mortality-surveys NIOSH-Grant NIOSH-Publication Occupational Diseases Respiratory-system-disorders Risk-factors Training

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  139
• Issue:
  12
• NIOSHTIC Number:
  nn:00222540
• Citation:
  Am J Epidemiol 1994 Jun; 139(12):1210-1222
• Contact Point Address:
  Dr. David H. Garabrant, Occupational Health Program, Department of Environmental and Industrial Health, University of Michigan School of Public Health, 1420 Washington Heights, Ann Arbor, Ml 48109-2029
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Sertraline (CAS RN 79617-96-2)
• Federal Fiscal Year:
  1994
• Performing Organization:
  University of Michigan at Ann Arbor, Ann Arbor, Michigan
• Peer Reviewed:
  True
• Start Date:
  19820701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  19950630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a7e2be2d752ecf8212040b29cf3889f94085dc9b9ded9902a2d9278cf0e70d92cf609ab3160a13e4626534376045dbec06a7e4a49155770b2d7b744af3f0901e
• Download URL:
  https://stacks.cdc.gov/view/cdc/204020/cdc_204020_DS1.pdf
• File Type:
  [PDF - 914.43 KB ]